Molecular structure of D-Mannose-6-phosphate, Disodium Salt, CAS Number: 33068-18-7
D-Mannose-6-phosphate, Disodium Salt (CAS 33068-18-7)
Alternate Names:
disodium (3,4,5,6-tetrahydroxytetrahydropyran-2-yl)methyl phosphate
Application:
D-Mannose-6-phosphate, Disodium Salt is a targeting signal for lysosomal hydrolases
CAS Number:
33068-18-7
Purity:
≥97%
Molecular Weight:
304.1
Molecular Formula:
C6H11O9P•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
D-Mannose-6-phosphate, Disodium Salt (M6P) is a molecule bound by lectin, which functions as a targeting signal for lysosomal hydrolases. The cells with D-Mannose-6-phosphate, Disodium Salt markers are recognized by specific receptors mediating their transport to an endosomal/prelysosomal compartment where they will be degraded by lysosomes. Furthermore, D-Mannose-6-phosphate can be converted into various isomers including, the isomer D-fructose 6-phosphate enzymatically using Mannose 6-phosphate isomerase.
D-Mannose-6-phosphate, Disodium Salt (CAS 33068-18-7) References
- Glycogen autophagy in newborn rat hepatocytes. | Kalamidas, SA. and Kotoulas, OB. 2000. Histol Histopathol. 15: 1011-8. PMID: 11005224
- Radioimmunoassay of soluble insulin-like growth factor-II/mannose 6-phosphate receptor: developmental regulation of receptor release by rat tissues in culture. | Bobek, G., et al. 1992. Endocrinology. 130: 3387-94. PMID: 1317782
- Human mononuclear phagocytes express the insulin-like growth factor-II/mannose-6-phosphate receptor. | Rom, WN. 1991. Am J Respir Cell Mol Biol. 4: 555-9. PMID: 1647180
- Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the mannose 6-phosphate isomerase from Salmonella typhimurium. | Gowda, G., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 81-4. PMID: 18259054
- Mannose-6-phosphate/insulin-like growth factor-II receptor in human melanoma cells: effect of ligands and antibodies on the receptor expression. | Laube, F. 2009. Anticancer Res. 29: 1383-8. PMID: 19414391
- Mannose phosphorylation in health and disease. | Kollmann, K., et al. 2010. Eur J Cell Biol. 89: 117-23. PMID: 19945768
- DFT investigation on the reaction mechanism catalyzed by α-phosphomannomutase1 in protonated/deprotonated states. | Chu, HY., et al. 2011. J Mol Model. 17: 577-85. PMID: 20512605
- Post-slaughter changes in ATP metabolites, reducing and phosphorylated sugars in chicken meat. | Aliani, M., et al. 2013. Meat Sci. 94: 55-62. PMID: 23376434
- Unusual binding sites for horseradish peroxidase on the surface of cultured and isolated mammalian cells. Suppression of binding by certain nucleotides and glycoproteins, and a role for calcium. | Straus, W. and Keller, JM. 1986. Histochemistry. 85: 277-85. PMID: 3093411
- Enzymatic characteristics of D-mannose 2-epimerase, a new member of the acylglucosamine 2-epimerase superfamily. | Saburi, W., et al. 2019. Appl Microbiol Biotechnol. 103: 6559-6570. PMID: 31201453
- Targeting STING Activation by Antigen-Inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy. | Gu, Y., et al. 2023. Adv Healthc Mater. e2300028. PMID: 36876892
- Characterization of latent TGF-beta activation by murine peritoneal macrophages. | Nunes, I., et al. 1995. J Immunol. 155: 1450-9. PMID: 7636210
- Carbohydrate-binding profile of a pregnancy-associated rat uterine glycoprotein. | Das, M., et al. 1994. Mol Cell Biochem. 137: 91-9. PMID: 7845392
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Mannose-6-phosphate, Disodium Salt, 50 mg | sc-203019 | 50 mg | $154.00 | |||
D-Mannose-6-phosphate, Disodium Salt, 1 g | sc-203019A | 1 g | $740.00 |