D,L-O-Desmethyl Venlafaxine-d6
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D,L-O-Desmethyl Venlafaxine-d6 is a deuterium-labeled metabolite of Venlafaxine (sc-201102). Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake. In vitro studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.
D,L-O-Desmethyl Venlafaxine-d6 References
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- Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers. | Blier, P., et al. 2007. Int J Neuropsychopharmacol. 10: 41-50. PMID: 16690005
- CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. | Shams, ME., et al. 2006. J Clin Pharm Ther. 31: 493-502. PMID: 16958828
- In vivo effect of venlafaxine on locus coeruleus neurons: role of opioid, alpha(2)-adrenergic, and 5-hydroxytryptamine(1A) receptors. | Berrocoso, E. and Mico, JA. 2007. J Pharmacol Exp Ther. 322: 101-7. PMID: 17431134
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- Venlafaxine: a new antidepressant drug. | Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D,L-O-Desmethyl Venlafaxine-d6, 1 mg | sc-218055 | 1 mg | $380.00 |