Date published: 2025-11-8

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D-Histidine (CAS 351-50-8)

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Application:
D-Histidine is an essential amino acid inactive isomer
CAS Number:
351-50-8
Purity:
≥98%
Molecular Weight:
155.15
Molecular Formula:
C6H9N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Histidine is a key component in the synthesis of proteins and plays a role in the catalytic activity of enzymes. It acts as a chelating agent, binding to metal ions and facilitating various biochemical reactions within cells. D-Histidine is involved in the regulation of pH levels within cells and the proper functioning of certain metabolic pathways. At the molecular level, D-Histidine interacts with other molecules to form stable complexes, which are integral to the structure and function of proteins. Its ability to donate and accept protons may be an important participant in acid-base reactions, contributing to the stability and functionality of biological systems. D-Histidine′s mechanism of action involves its participation in the formation of metalloproteins and its role in the coordination of metal ions within the active sites of enzymes.


D-Histidine (CAS 351-50-8) References

  1. L-histidine but not D-histidine attenuates brain edema following cryogenic injury in rats.  |  Ikeda, Y., et al. 2000. Acta Neurochir Suppl. 76: 195-7. PMID: 11450005
  2. Occurrence of D-histidine residues in antimicrobial poly(arginyl-histidine), conferring resistance to enzymatic hydrolysis.  |  Nishikawa, M. and Ogawa, K. 2004. FEMS Microbiol Lett. 239: 255-9. PMID: 15476974
  3. Chiral histidine selection by D-ribose RNA.  |  Illangasekare, M., et al. 2010. RNA. 16: 2370-83. PMID: 20940341
  4. D-histidine and L-histidine attenuate zinc-induced neuronal death in GT1-7 cells.  |  Kawahara, M., et al. 2013. Metallomics. 5: 453-60. PMID: 23503404
  5. Enantioselective Dynamic Self-Assembly of Histidine Droplets on Pillar[5]arene-Modified Interfaces.  |  Ma, J., et al. 2019. ACS Appl Mater Interfaces. 11: 1665-1671. PMID: 30561183
  6. Stereospecific interactions between histidine and monoclonal antibodies.  |  Baek, Y., et al. 2019. Biotechnol Bioeng. 116: 2632-2639. PMID: 31286487
  7. Shape-morphing living composites.  |  Rivera-Tarazona, LK., et al. 2020. Sci Adv. 6: eaax8582. PMID: 32010767
  8. Colorimetric detection of serum doxycycline with d-histidine-functionalized gold nanoclusters as nanozymes.  |  Song, Y., et al. 2020. Analyst. 145: 3564-3568. PMID: 32307504
  9. Synergistic effects of D-arginine, D-methionine and D-histidine against Porphyromonas gingivalis biofilms.  |  Zhang, Z., et al. 2021. Biofouling. 37: 222-234. PMID: 33682548
  10. Enantioselective Discrimination of Histidine by Means of an Achiral Cubane-Bridged Bis-Porphyrin.  |  Bettini, S., et al. 2021. Langmuir. 37: 13882-13889. PMID: 34784714
  11. Pair of chiral 2D silver(I) enantiomers: chiral recognition of L- and D-histidine via differential pulse voltammetry.  |  Kim, D., et al. 2022. Dalton Trans. 51: 6046-6052. PMID: 35353103
  12. Utilization of the D-isomers of arginine and histidine by chicks and rats.  |  Baker, DH. and Boebel, KP. 1981. J Anim Sci. 53: 125-9. PMID: 7319936
  13. D-histidine utilization in Salmonella typhimurium is controlled by the leucine-responsive regulatory protein (Lrp).  |  Hecht, K., et al. 1996. J Bacteriol. 178: 327-31. PMID: 8550449

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Histidine, 5 g

sc-255057
5 g
$110.00