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D-Glucuronic acid (CAS 6556-12-3)

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Alternate Names:
Glucosiduronic acid
CAS Number:
6556-12-3
Purity:
≥98%
Molecular Weight:
194.19
Molecular Formula:
C6H10O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Glucuronic acid is a white crystalline substance and possesses solubility in water. This compound is versatile, finding numerous applications in scientific research. It is used as a reference standard for calibrating analytical tools like HPLC and GC-MS. It also acts as a substrate for various enzymes, including glucose oxidase and lactonase. Moreover, D-Glucuronic acid serves as a model sugar acid, aiding in the study of several biological processes including carbohydrate metabolism and signaling pathways.


D-Glucuronic acid (CAS 6556-12-3) References

  1. A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers.  |  Kovensky, J., et al. 1999. Bioorg Med Chem. 7: 1567-80. PMID: 10482449
  2. The chemical synthesis of D-glucuronic acid.  |  MEHLTRETTER, CL. 1953. Adv Carbohydr Chem. 8: 231-49. PMID: 13138386
  3. The conjugates of d-glucuronic acid of animal origin.  |  TEAGUE, RS. 1954. Adv Carbohydr Chem. 9: 185-246. PMID: 13217911
  4. Stimulatory effect of barbital on urinary excretion of L-ascorbic acid and nonconjugated D-glucuronic acid.  |  BURNS, JJ., et al. 1957. J Biol Chem. 227: 785-94. PMID: 13463000
  5. Enzymic phosphorylation of D-glucuronic acid by extracts from seedlings of Phaseolus aureus.  |  NEUFELD, EF., et al. 1959. Arch Biochem Biophys. 83: 96-100. PMID: 13661996
  6. Structural determination of five novel tetrasaccharides containing 3-O-sulfated D-glucuronic acid and two rare oligosaccharides containing a beta-D-glucose branch isolated from squid cartilage chondroitin sulfate E.  |  Kinoshita-Toyoda, A., et al. 2004. Biochemistry. 43: 11063-74. PMID: 15323565
  7. Density functional study of the conformational space of 4C1 D-glucuronic acid.  |  Nyerges, B. and Kovács, A. 2005. J Phys Chem A. 109: 892-7. PMID: 16838961
  8. The Hofer-Moest decarboxylation of D-glucuronic acid and D-glucuronosides.  |  Stapley, JA. and Bemiller, JN. 2007. Carbohydr Res. 342: 610-3. PMID: 17229411
  9. Detection and quantification of D-glucuronic acid in human bile using 1H NMR spectroscopy: relevance to the diagnosis of pancreatic cancer.  |  Bezabeh, T., et al. 2009. MAGMA. 22: 267-75. PMID: 19390887
  10. A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent.  |  Kattel, K., et al. 2011. ACS Appl Mater Interfaces. 3: 3325-34. PMID: 21853997
  11. Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound.  |  Amaniampong, PN., et al. 2017. Sci Rep. 7: 40650. PMID: 28084448
  12. Biosynthesis of L-iduronic acid in heparin: epimerization of D-glucuronic acid on the polymer level.  |  Lindahl, U., et al. 1972. Biochem Biophys Res Commun. 46: 985-91. PMID: 4621648
  13. Structure of pig skin dermatan sulfate. 1. Distribution of D-glucuronic acid residues.  |  Fransson, LA. and Malmström, A. 1971. Eur J Biochem. 18: 422-30. PMID: 5542951
  14. Application of a radical reaction to the synthesis of l-iduronic acid derivatives from d-glucuronic acid analogues☆  |  T Chiba, P Sinaÿ - Carbohydrate research, 1986 - Elsevier. 15 August 1986,. Carbohydrate Research. Volume 151,: Pages 379-389.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Glucuronic acid, 10 mg

sc-221491
10 mg
$36.00

D-Glucuronic acid, 10 g

sc-221491A
10 g
$122.00