D-Galactopyranosyl-β-D-thiogalactopyranoside (CAS 51555-87-4)
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D-Galactopyranosyl-β- D-thiogalactopyranoside (Thiodigalactoside) is a compound belonging to the dihexoses (disaccharides containing two hexose carbohydrates). Thiodigalactoside is known to target galectin-1, heat-labile enterotoxin b chain, neurocan core protein, and lactose permease.
D-Galactopyranosyl-β- D-thiogalactopyranoside is often used to study galectins, a family of glycan-binding lectins with diverse regulatory roles in physiological processes. Galectins have significant roles in inflammation and cancer. Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 µM. It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.
D-Galactopyranosyl-β-D-thiogalactopyranoside (CAS 51555-87-4) References
- Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease. | Sondej, M., et al. 2002. Biochemistry. 41: 5556-65. PMID: 11969416
- Characterization of a lactose permease mutant that binds IIAGlc in the absence of ligand. | Sondej, M., et al. 2003. Biochemistry. 42: 9153-9. PMID: 12885249
- Sugar binding induces an outward facing conformation of LacY. | Smirnova, I., et al. 2007. Proc Natl Acad Sci U S A. 104: 16504-9. PMID: 17925435
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- Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. | van Hattum, H., et al. 2013. J Med Chem. 56: 1350-4. PMID: 23281927
- Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. | Kuo, P., et al. 2014. Clin Cancer Res. 20: 5558-69. PMID: 25189484
- Galectins in cancer: carcinogenesis, diagnosis and therapy. | Ebrahim, AH., et al. 2014. Ann Transl Med. 2: 88. PMID: 25405163
- Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia. | Than, NG., et al. 2015. J Pathol Transl Med. 49: 181-208. PMID: 26018511
- Purification in high yield and characterisation of the galactose-specific lectin from the seeds of snake gourd (Trichosanthes anguina). | Komath, SS., et al. 1996. Biochem Mol Biol Int. 39: 243-52. PMID: 8799450
- Galectin-8 tandem-repeat structure is essential for T-cell proliferation but not for co-stimulation | Cattaneo, V., Tribulatti, M. V., & Campetella, O. 2011. Biochemical Journal. 434(1): 153-160.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Galactopyranosyl-β-D-thiogalactopyranoside, 100 mg | sc-285346 | 100 mg | $107.00 | |||
D-Galactopyranosyl-β-D-thiogalactopyranoside, 250 mg | sc-285346A | 250 mg | $161.00 |