Molecular structure of D-Erythrose 4-phosphate sodium salt, CAS Number: 103302-15-4
D-Erythrose 4-phosphate sodium salt (CAS 103302-15-4)
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Alternate Names:
D-Erythrose 4-phosphate sodium salt is also known as E4P.
Application:
D-Erythrose 4-phosphate sodium salt is used as a substrate for synthase characterization, identification, and differentiation.
CAS Number:
103302-15-4
Molecular Weight:
222.07
Molecular Formula:
C4H8NaO7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-Erythrose 4-phosphate sodium salt is used as a substrate to identify, differentiate and characterize various synthases that intitate the shikimate pathway in microorganisms and plants. It is a key part of the pentose phosphate pathway and acts as an intermediate not only for pentose phosphate, but for phenylalanine, tyrosine, tryptophan, and vitamin B6 metabolism as well. Malaria researchers have worked with D-Erythrose 4-phosphate sodium salt as an inhibitor of the PfPdx1 component of the PLP synthase enzymatic complex.
D-Erythrose 4-phosphate sodium salt (CAS 103302-15-4) References
- Biosynthesis of 1-deoxy-1-imino-D-erythrose 4-phosphate: a defining metabolite in the aminoshikimate pathway. | Guo, J. and Frost, JW. 2002. J Am Chem Soc. 124: 528-9. PMID: 11804477
- Escherichia coli YrbH is a D-arabinose 5-phosphate isomerase. | Meredith, TC. and Woodard, RW. 2003. J Biol Chem. 278: 32771-7. PMID: 12805358
- THE FORMATION OF ERYTHRONIC ACID 4-PHOSPHATE FROM ERYTHROSE 4-PHOSPHATE BY GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE. | ISHII, Y., et al. 1964. J Biochem. 56: 111-2. PMID: 14202228
- Designing a metal-binding site in the scaffold of Escherichia coli KDO8PS. | Oliynyk, Z., et al. 2004. Protein Eng Des Sel. 17: 383-90. PMID: 15166313
- Bacillus subtilis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase revisited: resolution of two long-standing enigmas. | Wu, J., et al. 2005. Biochem J. 390: 583-90. PMID: 15869469
- Enzymatic Basis for Overproduction of Tryptophan and Its Metabolites in Hansenula polymorpha Mutants. | Denenu, EO. and Demain, AL. 1981. Appl Environ Microbiol. 42: 497-501. PMID: 16345845
- Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum. | Müller, IB., et al. 2009. PLoS One. 4: e4406. PMID: 19197387
- Modular engineering of L-tyrosine production in Escherichia coli. | Juminaga, D., et al. 2012. Appl Environ Microbiol. 78: 89-98. PMID: 22020510
- Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum. | Reeksting, SB., et al. 2013. Biochem J. 449: 175-87. PMID: 23039077
- Cloning and heterologous overexpression of three gap genes encoding different glyceraldehyde-3-phosphate dehydrogenases from the plant pathogenic bacterium Pseudomonas syringae pv. tomato strain DC3000. | Elkhalfi, B., et al. 2013. Protein Expr Purif. 89: 146-55. PMID: 23507306
- Intracellular hydrogen peroxide and superoxide poison 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, the first committed enzyme in the aromatic biosynthetic pathway of Escherichia coli. | Sobota, JM., et al. 2014. J Bacteriol. 196: 1980-91. PMID: 24659765
- Mutational analysis of the catalytic and feedback sites of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli. | Ray, JM., et al. 1988. J Bacteriol. 170: 5500-6. PMID: 2903857
- Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. | Liu, R., et al. 2019. Nat Commun. 10: 991. PMID: 30824700
- Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis. | Zhao, G., et al. 1995. J Bacteriol. 177: 2804-12. PMID: 7751290
- An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth. | Zhao, G. and Winkler, ME. 1994. J Bacteriol. 176: 6134-8. PMID: 7928977
- Purification and characterization of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Streptomyces rimosus. | Stuart, F. and Hunter, IS. 1993. Biochim Biophys Acta. 1161: 209-15. PMID: 8094298
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TKTL2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Erythrose 4-phosphate sodium salt, 5 mg | sc-214801 | 5 mg | $190.00 | |||
D-Erythrose 4-phosphate sodium salt, 10 mg | sc-214801B | 10 mg | $307.00 | |||
D-Erythrose 4-phosphate sodium salt, 25 mg | sc-214801A | 25 mg | $525.00 | |||
D-Erythrose 4-phosphate sodium salt, 100 mg | sc-214801C | 100 mg | $1632.00 |