Molecular structure of D-erythro-N,N-Dimethylsphingosine, CAS Number: 119567-63-4
D-erythro-N,N-Dimethylsphingosine (CAS 119567-63-4)
Application:
D-erythro-N,N-Dimethylsphingosine is a general protein kinase modulator
CAS Number:
119567-63-4
Purity:
>97%
Molecular Weight:
327.50
Molecular Formula:
C20H41NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-erythro-N,N-Dimethylsphingosine is a general modulator of protein kinases.
D-erythro-N,N-Dimethylsphingosine (CAS 119567-63-4) References
- D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | Xu, CB., et al. 2002. Atherosclerosis. 164: 237-43. PMID: 12204793
- Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. | Yun, JK. and Kester, M. 2002. Arch Biochem Biophys. 408: 78-86. PMID: 12485605
- Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. | Nakamura, H., et al. 2004. Eur J Pharmacol. 484: 9-17. PMID: 14729377
- Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. | Min, J., et al. 2004. Eukaryot Cell. 3: 795-805. PMID: 15190000
- N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. | Wang, H., et al. 2008. Mol Cancer Ther. 7: 2967-76. PMID: 18790777
- The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. | McDonald, RA., et al. 2010. Br J Pharmacol. 159: 543-53. PMID: 20015089
- A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. | Igarashi, Y., et al. 1990. J Biol Chem. 265: 5385-9. PMID: 2318819
- Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities. | Igarashi, Y., et al. 1989. Biochemistry. 28: 6796-800. PMID: 2479412
- Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation. | Nagata, Y., et al. 2014. Exp Cell Res. 326: 112-24. PMID: 24960577
- Sphingolipid pathway regulates innate immune responses at the fetomaternal interface during pregnancy. | Mizugishi, K., et al. 2015. J Biol Chem. 290: 2053-68. PMID: 25505239
Inhibitor of:
SphK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-erythro-N,N-Dimethylsphingosine, 5 mg | sc-211175 | 5 mg | $65.00 |