Date published: 2026-4-26

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D-erythro-Chloramphenicol (CAS 7387-98-6)

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Alternate Names:
[S-(R*,S*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamide
CAS Number:
7387-98-6
Molecular Weight:
323.13
Molecular Formula:
C11H12Cl2N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-erythro-Chloramphenicol is an antibiotic that functions by inhibiting protein synthesis in bacteria. It binds to the 50S ribosomal subunit, to the peptidyl transferase center, and prevents the formation of peptide bonds during translation. This interference with protein synthesis ultimately leads to the inhibition of bacterial growth. D-erythro-Chloramphenicol mode of action involves blocking the peptidyl transferase activity of the ribosome, thereby disrupting the elongation of the polypeptide chain. This disruption results in the accumulation of incomplete proteins within the bacterial cell, leading to its eventual death. D-erythro-Chloramphenicol′s mechanism of action at the molecular level involves interfering with the ribosome′s ability to catalyze the formation of peptide bonds between amino acids, thereby disrupting the synthesis of bacterial proteins.


D-erythro-Chloramphenicol (CAS 7387-98-6) References

  1. URINARY TRYPSIN INHIBITOR (MINGIN): TRANSFORMATION INTO A NEW TRYPSIN INHIBITOR BY ACID HYDROLYSIS OR BY SIALIDASE.  |  ASTRUP, T. and NISSEN, U. 1964. Nature. 203: 255-7. PMID: 14201757
  2. UPTAKE AND BINDING OF CHLORAMPHENICOL BY SENSITIVE AND RESISTANT ORGANISMS.  |  VAZQUEZ, D. 1964. Nature. 203: 257-8. PMID: 14201758
  3. Enantioselective analysis of chloramphenicol residues in honey samples by chiral LC-MS/MS and results of a honey survey.  |  Rimkus, GG. and Hoffmann, D. 2017. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 34: 950-961. PMID: 28406359
  4. Screening of stereoisomeric chloramphenicol residues in honey by ELISA and CHARM ® II test - the potential risk of systematically false-compliant (false negative) results.  |  Rimkus, GG., et al. 2020. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 37: 94-103. PMID: 31697202
  5. Biotransformation of antibiotics. II. Investigation of the chloramphenicol acetyltransferase in Streptomyces griseus.  |  El-Kersh, TA. and Plourde, JR. 1976. J Antibiot (Tokyo). 29: 1189-98. PMID: 825495

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-erythro-Chloramphenicol, 10 mg

sc-504794
10 mg
$388.00