(D) DT-2
Alternate Names:
PKG Inhibitor Peptide, YGRKKRRQRRRPPLRKKKKKH-NH2 (all-d)
Application:
(D) DT-2 is A potent, cell permeable and highly selective polypeptide inhibitor of cGMP dependent protein kinase 1α
Molecular Weight:
2800.5 (free peptide)
Molecular Formula:
C122H223N53O23 (free peptide)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(D) DT-2 is a potent, cell permeable and highly selective polypeptide inhibitor of cGMP dependent protein kinase 1α (Ki = 0.8 nM). This compound has shown approximately 15,000 fold selectivity for PKG-1α over other cAMP-dependent protein kinases. gene id 5592 for PKG 1 beta (splice variant). RG
(D) DT-2 References
- (D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha. | Nickl, CK., et al. 2010. Biochim Biophys Acta. 1804: 524-32. PMID: 20018259
- The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells. | Gambaryan, S., et al. 2012. Br J Pharmacol. 167: 826-38. PMID: 22612416
- cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation. | Bucci, M., et al. 2012. PLoS One. 7: e53319. PMID: 23285278
- cGMP-Dependent Protein Kinase Inhibitors in Health and Disease. | Wolfertstetter, S., et al. 2013. Pharmaceuticals (Basel). 6: 269-86. PMID: 24275951
- LncRNA EMX2OS, Regulated by TCF12, Interacts with FUS to Regulate the Proliferation, Migration and Invasion of Prostate Cancer Cells Through the cGMP-PKG Signaling Pathway. | Wang, Z., et al. 2020. Onco Targets Ther. 13: 7045-7056. PMID: 32801740
- New phiocricetomyine rodents (Hystricognathi) from the Jebel Qatrani Formation, Fayum Depression, Egypt. | Al-Ashqar, SF., et al. 2021. PeerJ. 9: e12074. PMID: 34721955
- EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway. | Li, X., et al. 2024. Open Med (Wars). 19: 20230875. PMID: 38205153
Inhibitor of:
cGKI alpha, and cGKI beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(D) DT-2, 500 µg | sc-361974 | 500 µg | $364.00 |