Molecular structure of D-Cycloserine, CAS Number: 339-72-0
D-Cycloserine (CAS 68-41-7)
See product citations (4)
Alternate Names:
(R)-4-Amino-3-isoxazolidone
Application:
D-Cycloserine is antibiotic and a partial agonist of NMDA receptors at the glycine modulatory site
CAS Number:
68-41-7
Purity:
≥98%
Molecular Weight:
102.09
Molecular Formula:
C3H6N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-Cycloserine is a partial agonist of NMDA receptors at the glycine site. D-Cycloserine has experimentally been shown to facilitate activation of the receptor and thereby improve memory and cognition. An amino acid analog, D-Cycloserine inhibits bacterial cell wall biosynthesis.
D-Cycloserine (CAS 68-41-7) References
- Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. | Tsai, GE., et al. 1999. Am J Psychiatry. 156: 467-9. PMID: 10080566
- Effects of D-cycloserine, a positive modulator of N-methyl-D-aspartate receptors, and ST 587, a putative alpha-1 adrenergic agonist, individually and in combination, on the non-delayed and delayed foraging behaviour of rats assessed in the radial arm maze. | Pussinen, R. and Sirviö, J. 1999. J Psychopharmacol. 13: 171-9. PMID: 10475724
- RS 67333 and D-cycloserine accelerate learning acquisition in the rat. | Lelong, V., et al. 2001. Neuropharmacology. 41: 517-22. PMID: 11543772
- THE ENZYMATIC SYNTHESIS OF D-ALANYL-D-ALANINE. 3. ON THE INHIBITION OF D-ALANYL-D-ALANINE SYNTHETASE BY THE ANTIBIOTIC D-CYCLOSERINE. | NEUHAUS, FC. and LYNCH, JL. 1964. Biochemistry. 3: 471-80. PMID: 14188160
- A pilot study of D-cycloserine in subjects with autistic disorder. | Posey, DJ., et al. 2004. Am J Psychiatry. 161: 2115-7. PMID: 15514414
- Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. | Ressler, KJ., et al. 2004. Arch Gen Psychiatry. 61: 1136-44. PMID: 15520361
- A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. | Norberg, MM., et al. 2008. Biol Psychiatry. 63: 1118-26. PMID: 18313643
- Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. | Dravid, SM., et al. 2010. J Neurosci. 30: 2741-54. PMID: 20164358
- Impaired extinction retention in adolescent rats: effects of D-cycloserine. | McCallum, J., et al. 2010. Neuropsychopharmacology. 35: 2134-42. PMID: 20592716
- A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression. | Heresco-Levy, U., et al. 2013. Int J Neuropsychopharmacol. 16: 501-6. PMID: 23174090
- D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. | Hood, WF., et al. 1989. Neurosci Lett. 98: 91-5. PMID: 2540460
- Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W. | Lambert, MP. and Neuhaus, FC. 1972. J Bacteriol. 110: 978-87. PMID: 4555420
- Mechanism of D-cycloserine action: transport mutants for D-alanine, D-cycloserine, and glycine. | Wargel, RJ., et al. 1971. J Bacteriol. 105: 1028-35. PMID: 4926674
- The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam. | Baran, H., et al. 1994. Brain Res. 652: 195-200. PMID: 7953730
- Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacterium smegmatis. | Cáceres, NE., et al. 1997. J Bacteriol. 179: 5046-55. PMID: 9260945
Inhibitor of:
AGXT2L1, AGXT2L2, Alk-SMase, ASAH2B, ASL, ASPDH, Brucella abortus LPS, C14orf149, EG632778, GCAT, GCSH, GluR-δ1, Glutamate-Pyruvate Transaminase, Gm853, LRFN5, LRTM2, MDGA1, NgR3, NP60, Olfr820, PDXDC1, PDXDC2, PGDH, PLP-F, PNPO, PSAT1, PSPH, pyridoxal phosphatase, RmlB, RV3134 Dormancy Regulon, Shank2, SLC38A8, SLC7A12, SNAT5, SPTLC1, SPTLC2, TDH, and Vmn2r102.Activator of:
CASKIN2, Cerebellin 4, densin-180, ESAT6, Grid2ip, GRIN1, Homer-3, LRFN3, LRFN5, LRRTM2, MT 38 kDa antigen, Mycobacterium avium, NETO1, Neuritin, NMDA, NMDAε2, NMDAε4, NR3A, PBP, PSD-95, RIM-BP3, Serine racemase, SerRSmt, Shank 1, SLC7A12, SLITRK1, Somatostatin, and SSTR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Cycloserine, 200 mg | sc-221470 | 200 mg | $28.00 | |||
D-Cycloserine, 1 g | sc-221470A | 1 g | $77.00 | |||
D-Cycloserine, 5 g | sc-221470B | 5 g | $142.00 | |||
D-Cycloserine, 25 g | sc-221470C | 25 g | $530.00 |