Date published: 2026-5-1

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D-Arginine monohydrochloride (CAS 627-75-8)

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CAS Number:
627-75-8
Molecular Weight:
210.66
Molecular Formula:
C6H14N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Arginine monohydrochloride (D-Arg-HCl) has been utilized to explore the impact of nitric oxide on vascular function, the effects of creatine on muscle endurance and strength, and the influence of arginine on the immune system. Additionally, it′s been used to investigate the role of arginine in wound healing and tissue regeneration. D-Arginine monohydrochloride serves as a precursor for nitric oxide (NO), a vital signaling molecule implicated in numerous physiological processes. It′s converted to NO by the enzyme called nitric oxide synthase (NOS). Once converted, NO is discharged into the bloodstream where it triggers various signaling pathways, including those involved in cell proliferation, inflammation, and vasodilation.


D-Arginine monohydrochloride (CAS 627-75-8) References

  1. D-arginase of Arthrobacter sp. KUJ 8602: characterization and its identity with Zn(2+)-guanidinobutyrase.  |  Arakawa, N., et al. 2003. J Biochem. 133: 33-42. PMID: 12761196
  2. ANTAGONISM OF THE D-FORMS OF THE ESSENTIAL AMINO ACIDS TOWARD THE PROMOTION OF GROWTH BY D-HISTIDINE.  |  Kamath, SH. and Berg, CP. 1964. J Nutr. 82: 243-8. PMID: 14135580
  3. INFLUENCE OF CERTAIN AMINO ACIDS AND OF NICOTINIC ACID UPON THE NICOTINE CONTENT OF TOBACCO LEAVES.  |  Dawson, RF. 1939. Plant Physiol. 14: 479-91. PMID: 16653576
  4. Nitric oxide modulates the firing rate of the rat supraoptic magnocellular neurons.  |  Ventura, RR., et al. 2008. Neuroscience. 155: 359-65. PMID: 18585443
  5. Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine.  |  Taksande, BG., et al. 2009. Neuropharmacology. 57: 415-24. PMID: 19589348
  6. Probing of L-arginine as an additive for the temperature-induced aggregation of veterinary growth hormones: fluorescence study.  |  Cirkovas, A. and Sereikaite, J. 2011. Mol Biotechnol. 49: 11-8. PMID: 21207196
  7. A Biocompatible Arginine-based Polycation.  |  Zern, BJ., et al. 2011. Adv Funct Mater. 21: 434-440. PMID: 23393493
  8. Protective effect of L-arginine on gentamicin-induced nephrotoxicity in rats.  |  Başhan, İ., et al. 2014. Indian J Pharmacol. 46: 608-12. PMID: 25538331
  9. STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium.  |  Phillips, RS., et al. 2017. Arch Biochem Biophys. 634: 83-87. PMID: 29024617
  10. Intracerebroventricular injection of L-arginine and D-arginine induces different effects under an acute stressful condition.  |  Tran, PV., et al. 2020. Biochem Biophys Res Commun. 533: 965-970. PMID: 33008589
  11. Vascular effects of acute hyperglycemia in humans are reversed by L-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia.  |  Giugliano, D., et al. 1997. Circulation. 95: 1783-90. PMID: 9107164

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Arginine monohydrochloride, 5 g

sc-257280
5 g
$79.00

D-Arginine monohydrochloride, 25 g

sc-257280A
25 g
$107.00

D-Arginine monohydrochloride, 100 g

sc-257280B
100 g
$331.00

D-Arginine monohydrochloride, 250 g

sc-257280C
250 g
$770.00

D-Arginine monohydrochloride, 1 kg

sc-257280D
1 kg
$2555.00