![[D-Arg<sup>1</sup>,D-Phe<sup>5</sup>,D-Trp<sup>7,9</sup>,Leu<sup>11</sup>]-Substance P (CAS 96736-12-8) - chemical structure image](https://media.scbt.com/product/d-arg1-d-phe5-d-trp7-9-leu11-substance-p-96736-12-8-structure_14_40_b_144025.jpg)
![[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P (CAS 96736-12-8) - chemical structure image](https://media.scbt.com/product/d-arg1-d-phe5-d-trp7-9-leu11-substance-p-96736-12-8-structure_14_40_t_144025.jpg "Molecular structure of [D-Arg<sup>1</sup>,D-Phe<sup>5</sup>,D-Trp<sup>7,9</sup>,Leu<sup>11</sup>]-Substance P, CAS Number: 96736-12-8")
Molecular structure of [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, CAS Number: 96736-12-8
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P (CAS 96736-12-8)
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Application:
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide antagonist and inverse agonist
CAS Number:
96736-12-8
Molecular Weight:
1516.85
Molecular Formula:
C79H109N19O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P has been shown to be a broad spectrum neuropeptide antagonist and inverse agonist. This compound has also been reported to be a potent full inverse agonist for the ghrelin receptor. Additional research has proven that this compound induces apoptosis and is also an antagonist at tachykinin, bradykinin, CCK and bombesin receptors.
[D-Arg,[object Object],,D-Phe,[object Object],,D-Trp,[object Object],,Leu,[object Object],]-Substance P (CAS 96736-12-8) References
- Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells. | Matsumoto, Y., et al. 2000. Anticancer Res. 20: 3123-9. PMID: 11062732
- High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. | Holst, B., et al. 2003. Mol Endocrinol. 17: 2201-10. PMID: 12907757
- In vitro effects of substance P analogue [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P on human tumour and normal cell growth. | Everard, MJ., et al. 1992. Br J Cancer. 65: 388-92. PMID: 1373071
- [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a neuropeptide antagonist, blocks binding, Ca2(+)-mobilizing, and mitogenic effects of endothelin and vasoactive intestinal contractor in mouse 3T3 cells. | Fabregat, I. and Rozengurt, E. 1990. J Cell Physiol. 145: 88-94. PMID: 1698796
- Ghrelin decreases microvascular leak during inflammation. | Kwan, RO., et al. 2010. J Trauma. 68: 1186-91. PMID: 20068486
- [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. | Woll, PJ. and Rozengurt, E. 1988. Proc Natl Acad Sci U S A. 85: 1859-63. PMID: 2450349
- [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P induces apoptosis in lung cancer cell lines in vitro. | Reeve, JG. and Bleehen, NM. 1994. Biochem Biophys Res Commun. 199: 1313-9. PMID: 7511895
- Stability and in vitro metabolism of the mitogenic neuropeptide antagonists [D-Arg1,D-Phe5, D-Trp7,9, Leu11]-substance P and [Arg6, D-Trp7,9, MePhe8]-substance P (6-11) characterized by high-performance liquid chromatography. | Cummings, J., et al. 1994. J Pharm Biomed Anal. 12: 811-9. PMID: 7522585
- Differential modulation of bombesin-stimulated phospholipase C beta and mitogen-activated protein kinase activity by [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P. | Mitchell, FM., et al. 1995. J Biol Chem. 270: 8623-8. PMID: 7536738
- [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P inhibits the growth of human small cell lung cancer xenografts in vivo. | Everard, MJ., et al. 1993. Eur J Cancer. 29A: 1450-3. PMID: 7691115
- [D-Arg1,D-Trp5,7,9,Leu11]Substance P coordinately and reversibly inhibits bombesin- and vasopressin-induced signal transduction pathways in Swiss 3T3 cells. | Seckl, MJ., et al. 1996. J Biol Chem. 271: 29453-60. PMID: 8910612
- Processing of [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P in xenograft bearing Nu/Nu mice. | Jones, DA., et al. 1997. Peptides. 18: 1073-7. PMID: 9357069
- [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. | Jarpe, MB., et al. 1998. J Biol Chem. 273: 3097-104. PMID: 9446627
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, 1 mg | sc-361166 | 1 mg | $94.00 |