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D-Arabinose 5-phosphate disodium salt (CAS 89927-09-3)

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Application:
D-Arabinose 5-phosphate disodium salt is a substrate to identify, differentiate and characterize enzymes
CAS Number:
89927-09-3
Purity:
≥95%
Molecular Weight:
274.07
Molecular Formula:
C5H9O8PNa2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Arabinose 5-phosphate disodium salt (CAS: 89927-09-3) plays a pivotal role in molecular biology research due to its involvement in the pentose phosphate pathway (PPP), a crucial metabolic route essential for nucleotide synthesis and oxidative stress response. As a derivative of arabinose, this chemical is instrumental in studying enzyme mechanics within the PPP, specifically those converting pentose sugars to nucleotide precursors. Researchers utilize D-Arabinose 5-phosphate disodium salt to dissect the functions and regulatory mechanisms of specific enzymes such as ribose-phosphate diphosphokinase, contributing to a deeper understanding of cellular metabolism and enzyme kinetics. Additionally, this compound serves as a valuable tool in genetic engineering, where it′s used to study and manipulate bacterial metabolic pathways. By altering the concentration of such pentose derivatives, scientists can observe changes in cellular processes, providing insights into metabolic control and pathway engineering. This has implications for improving the production of biochemicals, including amino acids and bioplastics, via engineered microbial systems. The ability to study these mechanisms in detail enhances our understanding of metabolic regulation and the potential for metabolic engineering in various microorganisms.


D-Arabinose 5-phosphate disodium salt (CAS 89927-09-3) References

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  2. 3-Deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli. Model of binding of phosphoenolpyruvate and D-arabinose-5-phosphate.  |  Wagner, T., et al. 2000. J Mol Biol. 301: 233-8. PMID: 10926505
  3. Biosynthesis of d-arabinose in Mycobacterium smegmatis: specific labeling from d-glucose.  |  Klutts, JS., et al. 2002. Arch Biochem Biophys. 398: 229-39. PMID: 11831854
  4. Escherichia coli YrbH is a D-arabinose 5-phosphate isomerase.  |  Meredith, TC. and Woodard, RW. 2003. J Biol Chem. 278: 32771-7. PMID: 12805358
  5. Arabinose 5-phosphate analogues as mechanistic probes for Neisseria meningitidis 3-deoxy-D-manno-octulosonate 8-phosphate synthase.  |  Ahn, M., et al. 2008. Bioorg Med Chem. 16: 9830-6. PMID: 18930408
  6. Targeting bacterial membranes: NMR spectroscopy characterization of substrate recognition and binding requirements of D-arabinose-5-phosphate isomerase.  |  Airoldi, C., et al. 2010. Chemistry. 16: 1897-902. PMID: 20039350
  7. Maillard reaction of ribose 5-phosphate generates superoxide and glycation products for bovine heart cytochrome c reduction.  |  Gersten, RA., et al. 2010. Carbohydr Res. 345: 2499-506. PMID: 20933223
  8. Analysis of the arabinose-5-phosphate isomerase of Bacteroides fragilis provides insight into regulation of single-domain arabinose phosphate isomerases.  |  Cech, D., et al. 2014. J Bacteriol. 196: 2861-8. PMID: 24891442
  9. Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications.  |  Chiu, HJ., et al. 2014. Acta Crystallogr D Biol Crystallogr. 70: 2640-51. PMID: 25286848
  10. Isolation of a mutant of Salmonella typhimurium dependent on D-arabinose-5-phosphate for growth and synthesis of 3-deoxy-D-mannoctulosonate (ketodeoxyoctonate).  |  Rick, PD. and Osborn, MJ. 1972. Proc Natl Acad Sci U S A. 69: 3756-60. PMID: 4566459
  11. Transport of D-arabinose-5-phosphate and D-sedoheptulose-7-phosphate by the hexose phosphate transport system of Salmonella typhimurium.  |  Eidels, L., et al. 1974. J Bacteriol. 119: 138-43. PMID: 4600697

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Arabinose 5-phosphate disodium salt, 25 mg

sc-221467
25 mg
$1022.00

D-Arabinose 5-phosphate disodium salt, 100 mg

sc-221467A
100 mg
$2191.00