Date published: 2025-10-15

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D-AP7 (CAS 81338-23-0)

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Alternate Names:
D(−)-2-Amino-7-phosphonoheptanoic acid
CAS Number:
81338-23-0
Molecular Weight:
225.18
Molecular Formula:
C7H16NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-AP7 is a compound utilized in neuroscientific research due to its role as a selective antagonist for the N-methyl-D-aspartate (NMDA) receptor. This receptor is involved in synaptic plasticity and neurotransmission, and D-AP7 is applied in studies to understand these processes by inhibiting the NMDA receptor function. Researchers use D-AP7 to explore the mechanisms of learning and memory, as well as to dissect the contributions of NMDA receptor activity to neural network dynamics and neurodegenerative conditions. In electrophysiological experiments, D-AP7 helps in elucidating the cellular responses to glutamate, the body′s primary excitatory neurotransmitter, and in distinguishing between the actions of various glutamate receptor subtypes. Additionally, D-AP7 is used in the investigation of neurotoxicity and neuroprotection, providing insights into the complex signaling pathways that govern neuronal survival and death.


D-AP7 (CAS 81338-23-0) References

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  2. N-methyl-D-aspartate receptors contribute to the baseline noise of retinal ganglion cells.  |  Gottesman, J. and Miller, RF. 2003. Vis Neurosci. 20: 329-33. PMID: 14570254
  3. Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the rat.  |  Kawabe, T., et al. 2008. Neuroscience. 153: 605-17. PMID: 18424005
  4. NMDA receptor antagonists attenuate a portion of the penicillin-induced epileptiform burst.  |  Watson, GB. and Lanthorn, TH. 1990. Brain Res Bull. 24: 765-8. PMID: 1973626
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  6. Effects of CA1 glutamatergic systems upon memory impairments in cholestatic rats.  |  Hosseini, N., et al. 2013. Behav Brain Res. 256: 636-45. PMID: 24050889
  7. The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task.  |  Nasehi, M., et al. 2015. Eur Neuropsychopharmacol. 25: 557-65. PMID: 25680309
  8. Medial Septal NMDA Glutamate Receptors are Involved in Modulation of Blood Natural Killer Cell Activity in Rats.  |  Podlacha, M., et al. 2016. J Neuroimmune Pharmacol. 11: 121-32. PMID: 26454750
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  13. Biphenyl-derivatives of 2-amino-7-phosphonoheptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonist--I. Pharmacological characterization in vitro.  |  Urwyler, S., et al. 1996. Neuropharmacology. 35: 643-54. PMID: 8887974

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-AP7, 10 mg

sc-500936
10 mg
$351.00