D-Amino Acid Oxidase Inhibitor (CAS 39793-31-2)
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D-Amino Acid Oxidase Inhibitor is a cell-permeable thienopyrrole compound that potently inhibits cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively). Exhibits no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
D-Amino Acid Oxidase Inhibitor (CAS 39793-31-2) References
- The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. | Sparey, T., et al. 2008. Bioorg Med Chem Lett. 18: 3386-91. PMID: 18455394
- The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. | Smith, SM., et al. 2009. J Pharmacol Exp Ther. 328: 921-30. PMID: 19088300
- Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity. | Major, LL. and Smith, TK. 2011. Mol Biol Int. 2011: 389364. PMID: 22091402
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Amino Acid Oxidase Inhibitor, 50 mg | sc-203909 | 50 mg | $130.00 |