Date published: 2025-10-15

1-800-457-3801

SCBT Portrait Logo
Seach Input

D-α-Hydroxyisovaleric acid (CAS 17407-56-6)

0.0(0)
Write a reviewAsk a question

Alternate Names:
(R)-2-Hydroxy-3-methylbutyric acid
Application:
D-α-Hydroxyisovaleric acid is used in the synthesis of peptides and depsipeptides
CAS Number:
17407-56-6
Purity:
≥97%
Molecular Weight:
118.13
Molecular Formula:
C5H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

D-α-Hydroxyisovaleric acid, referred to as (R)-2-hydroxyisobutyric acid (RHIBA), is an organic compound that occurs naturally in a diverse range of plants, animals, and microorganisms. D-α-Hydroxyisovaleric acid possesses chirality, stemming from a lone asymmetric carbon atom, and assumes significance as an intermediate in the biosynthesis of amino acids, fatty acids, and various other compounds. The applications of D-α-Hydroxyisovaleric acid in scientific research abound. It serves as a substrate for synthesizing diverse compounds, including amino acids, fatty acids, and other metabolites. Moreover, it finds utility as an analytical reagent, facilitating the determination of concentration levels of various compounds. Additionally, D-α-Hydroxyisovaleric acid assumes importance in biochemical and molecular biology studies, playing a role in the investigation of enzyme structure and function. It participates as a substrate in the Krebs cycle, a series of chemical reactions that generate cellular energy. Furthermore, in cell signaling, D-α-Hydroxyisovaleric acid plays a role in the generation of cyclic adenosine monophosphate (cAMP), a vital signaling molecule that regulates numerous cellular processes.


D-α-Hydroxyisovaleric acid (CAS 17407-56-6) References

  1. 13C NMR chemical shifts of the triclinic and monoclinic crystal forms of valinomycin.  |  Kameda, T., et al. 2004. J Biomol NMR. 29: 281-8. PMID: 15213426
  2. Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.  |  Cheng, YQ. 2006. Chembiochem. 7: 471-7. PMID: 16511823
  3. Structural studies on minor enniatins from Fusarium sp. VI 03441: novel N-methyl-threonine containing enniatins.  |  Uhlig, S., et al. 2009. Toxicon. 53: 734-42. PMID: 19249325
  4. Reconstituted biosynthesis of the nonribosomal macrolactone antibiotic valinomycin in Escherichia coli.  |  Jaitzig, J., et al. 2014. ACS Synth Biol. 3: 432-8. PMID: 24350980
  5. A new enniatin antibiotic from the endophyte Fusarium tricinctum Corda.  |  Zaher, AM., et al. 2015. J Antibiot (Tokyo). 68: 197-200. PMID: 25315756
  6. Increased valinomycin production in mutants of Streptomyces sp. M10 defective in bafilomycin biosynthesis and branched-chain α-keto acid dehydrogenase complex expression.  |  Lee, DW., et al. 2015. J Ind Microbiol Biotechnol. 42: 1507-17. PMID: 26335568
  7. Antiproliferative cyclodepsipeptides from the marine actinomycete Streptomyces sp. P11-23B downregulating the tumor metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis.  |  Ye, X., et al. 2017. Phytochemistry. 135: 151-159. PMID: 28049552
  8. Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.  |  Huguenin-Dezot, N., et al. 2019. Nature. 565: 112-117. PMID: 30542153
  9. Synthesis of beauvericin by a multifunctional enzyme.  |  Peeters, H., et al. 1988. J Antibiot (Tokyo). 41: 352-9. PMID: 3366693
  10. The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis.  |  Huang, S., et al. 2021. Microorganisms. 9: PMID: 33917912
  11. Genome-Scale Metabolic Modeling Combined with Transcriptome Profiling Provides Mechanistic Understanding of Streptococcus thermophilus CH8 Metabolism.  |  Rau, MH., et al. 2022. Appl Environ Microbiol. 88: e0078022. PMID: 35924931
  12. Stereocomplexation between PLA-like substituted oligomers and the influence on the hydrolytic degradation  |  Andersson, S. R., Hakkarainen, M., & Albertsson, A. C. 2013. Polymer. 54(16): 4105-4111.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-α-Hydroxyisovaleric acid, 1 g

sc-239638
1 g
$155.00