Molecular structure of D-α-Hydroxyglutaric acid disodium salt, CAS Number: 103404-90-6
D-α-Hydroxyglutaric acid disodium salt (CAS 103404-90-6)
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Alternate Names:
Sodium (R)-2-hydroxypentanedioate, 2R)-2-Hydroxypentanedioic Acid Disodium Salt
Application:
D-α-Hydroxyglutaric acid disodium salt is an α hydroxy acid and the product of the hydrolysis of (R)-5-oxo-2-tetrahydrofurancarboxylic acid.
CAS Number:
103404-90-6
Purity:
≥95%
Molecular Weight:
192.08
Molecular Formula:
C5H6O5•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-α-Hydroxyglutaric acid disodium salt is an alpha hydroxy acid, which is formed from the hydrolysis of (R)-5-oxo-2-tetrahydrofurancarboxylic acid. The enzyme Hydroxyacid-oxoacid transhydrogenase catalyzes the formation of D-α-Hydroxyglutaric acid disodium salt, whereas in bacteria it is catalyzed by 2-hydroxyglutarate synthase. Sodium (R)-2-hydroxypentanedioate exhibits a diverse array of biochemical and physiological impacts. It influences glucose metabolism, insulin sensitivity, and blood pressure regulation. It influences cell proliferation, apoptosis, and cell adhesion, as supported by scientific evidence.
D-α-Hydroxyglutaric acid disodium salt (CAS 103404-90-6) References
- Purification and characterization of a lactonase from Burkholderia sp. R-711, that hydrolyzes (R)-5-oxo-2-tetrahydrofurancarboxylic acid. | Mochizuki, K. 2001. Arch Microbiol. 175: 430-4. PMID: 11491083
- Alpha-hydroxyglutaric acid synthetase. | REEVES, HC. and AJL, SJ. 1962. J Bacteriol. 84: 186-7. PMID: 14491016
- Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. | Andronesi, OC., et al. 2012. Sci Transl Med. 4: 116ra4. PMID: 22238332
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. | Koivunen, P., et al. 2012. Nature. 483: 484-8. PMID: 22343896
- Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. | Gowda, P., et al. 2018. Mol Cell Biol. 38: PMID: 29463646
- Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma. | Miyake, K., et al. 2018. Med Oncol. 36: 11. PMID: 30506321
- [The effect of cytosine methylation in TTGGA(N5)TCCAA sequence of 5'-flanking region if the chicken betaH-globin gene on the interaction with TGGCA-binding protein in vitro]. | Lobanenkov, VV. 1988. Dokl Akad Nauk SSSR. 301: 1248-50. PMID: 3229304
- Identification and characterization of a novel mutant isocitrate dehydrogenase 1 inhibitor for glioma treatment. | Zhang, N., et al. 2021. Biochem Biophys Res Commun. 551: 38-45. PMID: 33714758
- [Experience in treating hereditary angioneurotic edema]. | Androsov, VN., et al. 1988. Ter Arkh. 60: 120-2. PMID: 3388262
- Urinary 2-Hydroxyglutarate Enantiomers Are Markedly Elevated in a Murine Model of Type 2 Diabetic Kidney Disease. | Baek, J. and Pennathur, S. 2021. Metabolites. 11: PMID: 34436410
- D2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment. | Yang, Q., et al. 2022. Mol Ther. 30: 1188-1200. PMID: 35007759
- An LKB1-mitochondria axis controls TH17 effector function. | Baixauli, F., et al. 2022. Nature. 610: 555-561. PMID: 36171294
- Development and validation of an LC-MS/MS method for D- and L-2-hydroxyglutaric acid measurement in cerebrospinal fluid, urine and plasma: application to glioma. | Dal-Bekar, NE., et al. 2022. Bioanalysis. 14: 1271-1280. PMID: 36453751
- The reversal of the myosin and actomyosin ATPase reactions and the free energy of ATP binding to myosin. | Wolcott, RG. and Boyer, PD. 1974. Biochem Biophys Res Commun. 57: 709-16. PMID: 4275131
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Fatso.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-α-Hydroxyglutaric acid disodium salt, 25 mg | sc-227739 | 25 mg | $122.00 | |||
D-α-Hydroxyglutaric acid disodium salt, 250 mg | sc-227739A | 250 mg | $820.00 | |||
D-α-Hydroxyglutaric acid disodium salt, 1 g | sc-227739B | 1 g | $2652.00 |