CZIB Antibody (H-5): sc-390866
- CZIB Antibody (H-5) is a mouse monoclonal IgG1 κ CZIB antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 99-115 within an internal region of CZIB of human origin
- CZIB Antibody (H-5) is recommended for detection of CZIB of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine, porcine and avian
- Anti-CZIB Antibody (H-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CZIB Antibody (H-5) for WB applications. These reagents are now offered in bundles with CZIB Antibody (H-5) (see ordering information below).
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CZIB Antibody (H-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CZIB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CZIB antibody (H-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CZIB plays a vital role in cellular processes by acting as a zinc-binding protein, essential for stabilizing protein structures and facilitating enzymatic reactions. Zinc ions, coordinated by specific motifs within CZIB, are crucial for numerous biological functions, including DNA and RNA synthesis, gene expression regulation, and apoptosis. CZIB′s ability to bind zinc contributes to structural integrity and enables participation in critical enzymatic activities, such as hydrolysis and redox reactions. CZIB′s significance in maintaining cellular homeostasis and involvement in various signaling pathways highlights importance in health and disease. Dysregulation of zinc-binding proteins like CZIB can lead to serious health issues, including neurodegenerative diseases, immune dysfunctions, and cancer, underscoring the necessity of understanding CZIB function and interactions within the cellular environment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CZIB Antibody (H-5) References:
- Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. | Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
- New insights into the evolution of chromosome 1. | Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
- Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. | McClintock, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 2154-9. PMID: 16461887
- Cell biology: ageing nucleus gets out of shape. | Lans, H. and Hoeijmakers, JH. 2006. Nature. 440: 32-4. PMID: 16511477
- Chromosome 1 abnormalities in multiple myeloma. | Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
- Lamin A-dependent nuclear defects in human aging. | Scaffidi, P. and Misteli, T. 2006. Science. 312: 1059-63. PMID: 16645051
- Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. | Hennah, W., et al. 2006. Schizophr Bull. 32: 409-16. PMID: 16699061
- The DNA sequence and biological annotation of human chromosome 1. | Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
- Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. | Watson, ML., et al. 1990. J Exp Med. 172: 263-72. PMID: 1694218
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CZIB Antibody (H-5) | sc-390866 | 200 µg/ml | $316.00 | |||
CZIB Antibody (H-5): m-IgG Fc BP-HRP Bundle | sc-530294 | 200 µg Ab; 10 µg BP | $354.00 | |||
CZIB Antibody (H-5): m-IgGκ BP-HRP Bundle | sc-523717 | 200 µg Ab, 40 µg BP | $354.00 | |||
CZIB Antibody (H-5): m-IgG1 BP-HRP Bundle | sc-543977 | 200 µg Ab; 20 µg BP | $354.00 | |||
CZIB Antibody (H-5) AC | sc-390866 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CZIB Antibody (H-5) HRP | sc-390866 HRP | 200 µg/ml | $316.00 | |||
CZIB Antibody (H-5) FITC | sc-390866 FITC | 200 µg/ml | $330.00 | |||
CZIB Antibody (H-5) PE | sc-390866 PE | 200 µg/ml | $343.00 | |||
CZIB Antibody (H-5) Alexa Fluor® 488 | sc-390866 AF488 | 200 µg/ml | $357.00 | |||
CZIB Antibody (H-5) Alexa Fluor® 546 | sc-390866 AF546 | 200 µg/ml | $357.00 | |||
CZIB Antibody (H-5) Alexa Fluor® 594 | sc-390866 AF594 | 200 µg/ml | $357.00 | |||
CZIB Antibody (H-5) Alexa Fluor® 647 | sc-390866 AF647 | 200 µg/ml | $357.00 | |||
CZIB Antibody (H-5) Alexa Fluor® 680 | sc-390866 AF680 | 200 µg/ml | $357.00 | |||
CZIB Antibody (H-5) Alexa Fluor® 790 | sc-390866 AF790 | 200 µg/ml | $357.00 | |||
CZIB (H-5) Neutralizing Peptide | sc-390866 P | 100 µg/0.5 ml | $68.00 |