Cytokeratin 9 Antibody (Ks9.70/Ks9.216): sc-58743

Cytokeratin 9 Antibody (Ks9.70/Ks9.216) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 9 protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Cytokeratin 9 antibody (Ks9.70/Ks9.216) is available as the non-conjugated format. Cytokeratin 9 is a crucial component of the cytoskeletal structure in epithelial cells, specifically expressed in the suprabasal layers of the epidermis, including the glandular ridges and interridges of the palms and soles. Cytokeratin 9 plays a vital role in maintaining the mechanical resilience and structural integrity of keratinized tissues, which is essential for protecting underlying tissues from physical and environmental stressors. The unique structure of Cytokeratin 9, characterized by head, α-helical coiled-coil rod, and tail domains, allows formation of stable filamentous networks that contribute to the overall strength of the epidermis. Mutations in the gene encoding Cytokeratin 9 are linked to epidermolytic palmoplantar keratoderma (EPPK), a genetic skin disorder that leads to severe thickening of the skin on the palms and soles, highlighting the importance of Cytokeratin 9 in skin health and disease.

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Cytokeratin 9 Antibody (Ks9.70/Ks9.216) References:

1. Cultured epithelial autograft 'take' confirmed by the presence of cytokeratin 9.  |  Stoner, ML. and Wood, FM. 1999. J Invest Dermatol. 112: 391-2. PMID: 10084321
2. Identification of the keratin K9 R162W mutation in patients of Italian origin with epidermolytic palmoplantar keratoderma.  |  Terrinoni, A., et al. 2004. Eur J Dermatol. 14: 375-8. PMID: 15564199
3. [Mutation analysis of keratin 9 gene in a pedigree with epidermolytic palmoplantar keratoderma].  |  Zhang, BR., et al. 2004. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21: 570-3. PMID: 15583984
4. A novel mutation of keratin 9 gene (R162P) in a Japanese family with epidermolytic palmoplantar keratoderma.  |  Kon, A., et al. 2005. Arch Dermatol Res. 296: 375-8. PMID: 15605275
5. The common KRT9 gene mutation in a Japanese patient with epidermolytic palmoplantar keratoderma and knuckle pad-like keratoses.  |  Hamada, T., et al. 2005. J Dermatol. 32: 500-2. PMID: 16043929
6. Distribution of a special subset of keratinocytes characterized by the expression of cytokeratin 9 in adult and fetal human epidermis of various body sites.  |  Moll, I., et al. 1987. Differentiation. 33: 254-65. PMID: 2439403
7. Molecular characterization of the body site-specific human epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and tissue specificity of gene expression.  |  Langbein, L., et al. 1993. Differentiation. 55: 57-71. PMID: 7507869