Cytokeratin 8 Antibody (Ks8.7): sc-101459

Cytokeratin 8 Antibody (Ks8.7) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 8 in mouse, rat, human, and hamster tissues through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 8 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Cytokeratin 8 is predominantly located in the cytoplasm of simple epithelial cells, where Cytokeratin 8 forms intermediate filaments that contribute to the overall architecture of the tissue. Cytokeratin 8 expression is particularly significant in epithelial differentiation and tumor characterization, as expression patterns often change in various malignancies. In squamous cell carcinomas derived from stratified epithelia, abnormal Cytokeratin 8 expression can indicate a shift in cellular phenotype associated with malignancy. Cytokeratin 8 expression has been identified as an independent prognostic marker in oral squamous cell carcinomas, correlating with poor patient outcomes. The ability of Cytokeratin 8 to present extracellular epitopes on tumor cells highlights potential therapeutic applications, making anti-Cytokeratin 8 antibody (Ks8.7) an invaluable tool for researchers studying epithelial biology and cancer progression.

The preferred Cytokeratin 8 antibody is Cytokeratin 8 Antibody (C51): sc-8020.