Cytokeratin 8 Antibody (35bH11): sc-58737

Cytokeratin 8 Antibody (35bH11) is a mouse monoclonal IgM antibody that detects Cytokeratin 8 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cytokeratin 8 antibody (35bH11) is available in a non-conjugated form, specifically designed for researchers seeking to study this important protein. Cytokeratin 8 is a member of the keratin family, which consists of a diverse group of intermediate filament proteins that are crucial for maintaining the structural integrity of epithelial cells. These proteins are primarily located in the cytoplasm of epithelial cells, where they form a network that provides mechanical support and resilience against stress. The presence of Cytokeratin 8 is particularly significant in simple epithelia, as Cytokeratin 8 plays a vital role in cellular differentiation and tissue specialization. Abnormal expression of Cytokeratin 8 has been associated with various malignancies, including squamous cell carcinomas, where Cytokeratin 8 can serve as a marker for tumor progression and prognosis. Notably, the expression of Cytokeratin 8 in oral squamous cell carcinomas has been identified as an independent prognostic factor, indicating a poor outcome for patients. Furthermore, the extracellular epitopes of Cytokeratin 8 on tumor cells present potential therapeutic targets, making Cytokeratin 8 a valuable focus for cancer research.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 8 Antibody (35bH11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 8 Antibody (35bH11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 8 Antibody (35bH11) Specifications

Alternate Product Name: KRT8

Product Clone Name: 35bH11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Hep3B hepatocellular carcinoma cell line

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 8 Antibody (35bH11): N/A

The preferred Cytokeratin 8 antibody is Cytokeratin 8 Antibody (C51): sc-8020.