Cytokeratin 16 Antibody (F-2): sc-271937

Cytokeratin 16 Antibody (F-2) is a mouse monoclonal IgM antibody that detects Cytokeratin 16 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cytokeratin 16 is a vital member of the cytokeratin family, which consists of intermediate filament proteins crucial for maintaining structural integrity of epithelial cells. Anti-Cytokeratin 16 antibody (F-2) recognizes proteins predominantly located in the cytoplasm of stratified squamous epithelial cells, where Cytokeratin 16 plays a significant role in providing mechanical support and resilience to cellular stress. Cytokeratin 16 expression is particularly important in skin and mucosal tissues, helping to protect against physical and chemical insults. Cytokeratin 16 serves as a valuable biomarker for identifying certain types of tumors, including squamous cell carcinoma of the head and neck, as well as benign lesions in the mammary gland and sweat ducts. Mutations in the Cytokeratin 16 gene are associated with several skin disorders, such as pachyonychia congenita type 1, highlighting Cytokeratin 16′s importance in both health and disease. Anti-Cytokeratin 16 antibody (F-2) is an essential tool for researchers studying epithelial biology and related pathologies.

The preferred Cytokeratin 16 antibody is Cytokeratin 16 Antibody (LL025): sc-53255.