Cytokeratin 15/18 Antibody (LC18N): sc-53254

Cytokeratin 15/18 Antibody (LC18N) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 15/18 in human samples through applications such as western blotting (WB) and immunofluorescence (IF). Cytokeratin 15/18 is a vital component of the intermediate filament protein family, playing a crucial role in maintaining structural integrity and mechanical stability of epithelial cells. Cytokeratin 15/18 proteins are predominantly located in epithelial cell cytoplasm, where these proteins form a network providing resilience against mechanical stress and contributing to cell shape and organization. Cytokeratin 15 serves as a specific marker for stem cells in hair follicle bulge, aiding in differentiation of basal cell carcinoma from trichoepithelioma, while Cytokeratin 18 is essential for keratin organization and is frequently expressed in various adenocarcinomas. Phosphorylation of Ser 18 in Cytokeratin 18 is a critical post-translational modification facilitating interaction with 14-3-3 proteins, underscoring Cytokeratin 15/18′s importance in cellular signaling pathways and potential implications in cancer biology. Anti-Cytokeratin 15/18 antibody (LC18N) is an invaluable tool for researchers studying epithelial cell biology, tissue differentiation, and characterization of malignant tumors.

The preferred Cytokeratin 18 antibody is Cytokeratin 18 Antibody (RGE53): sc-32329.