Cytokeratin 15/18 Antibody (LC18N): sc-53254

Cytokeratin 15/18 Antibody (LC18N) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 15/18 in human samples through applications such as western blotting (WB) and immunofluorescence (IF). Cytokeratin 15/18 is a vital component of the intermediate filament protein family, playing a crucial role in maintaining structural integrity and mechanical stability of epithelial cells. Cytokeratin 15/18 proteins are predominantly located in epithelial cell cytoplasm, where these proteins form a network providing resilience against mechanical stress and contributing to cell shape and organization. Cytokeratin 15 serves as a specific marker for stem cells in hair follicle bulge, aiding in differentiation of basal cell carcinoma from trichoepithelioma, while Cytokeratin 18 is essential for keratin organization and is frequently expressed in various adenocarcinomas. Phosphorylation of Ser 18 in Cytokeratin 18 is a critical post-translational modification facilitating interaction with 14-3-3 proteins, underscoring Cytokeratin 15/18′s importance in cellular signaling pathways and potential implications in cancer biology. Anti-Cytokeratin 15/18 antibody (LC18N) is an invaluable tool for researchers studying epithelial cell biology, tissue differentiation, and characterization of malignant tumors.

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Cytokeratin 15/18 Antibody (LC18N) References:

1. Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts.  |  Duan, WR., et al. 2003. J Pathol. 199: 221-8. PMID: 12533835
2. An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma.  |  Mahalingam, M., et al. 2012. Hum Pathol. 43: 1265-72. PMID: 22285043
3. Serum cytokeratin-18 in the diagnosis of non-alcoholic steatohepatitis: A meta-analysis.  |  Chen, J., et al. 2014. Hepatol Res. 44: 854-62. PMID: 23834322
4. Correlation between serum cytokeratin-18 and the progression or regression of non-alcoholic fatty liver disease.  |  Kawanaka, M., et al. 2015. Ann Hepatol. 14: 837-44. PMID: 26436355
5. Predictive value of serum caspase-cleaved cytokeratin-18 concentrations after acute intracerebral hemorrhage.  |  Gu, SJ., et al. 2016. Clin Chim Acta. 452: 124-8. PMID: 26569346
6. Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines.  |  Aztopal, N., et al. 2016. Oncol Lett. 12: 1429-1437. PMID: 27446448
7. The application of cytokeratin-18 as a biomarker for drug-induced liver injury.  |  Korver, S., et al. 2021. Arch Toxicol. 95: 3435-3448. PMID: 34322741
8. Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy.  |  Turczyn, A., et al. 2022. Cent Eur J Immunol. 47: 63-72. PMID: 35600153
9. Plasma Cytokeratin-18 Fragment Level Reflects the Metabolic Phenotype in Obesity.  |  Goralska, J., et al. 2023. Biomolecules. 13: PMID: 37189422
10. Visceral Obesity and Cytokeratin-18 Antigens as Early Biomarkers of Liver Damage.  |  de Alteriis, G., et al. 2023. Int J Mol Sci. 24: PMID: 37446065

The preferred Cytokeratin 18 antibody is Cytokeratin 18 Antibody (RGE53): sc-32329.