Cytochalasin H CAS: 53760-19-3
MF: C30H39NO5
MW: 493.6
A cell-permeable fungal toxin used in actin polymerization studies and cytological research.

Cytochalasin H (CAS 53760-19-3)

Cytochalasin H | CAS 53760-19-3 is rated 5.0 out of 5 by 1.
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Application: A cell-permeable fungal toxin used in actin polymerization studies and cytological research
CAS Number: 53760-19-3
Purity: >95%
Molecular Weight: 493.6
Molecular Formula: C30H39NO5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cytochalasin H is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. In vitro, cytochalasin H exhibits antibacterial, antifungal, nematocidal and antitumor activity.


References

1. Wells, J.M., et al. 1976. Can. J. Microbiol. 22: 1137-1143. PMID: 963626
2. Beno, M.A., et al. 1977. J. Am. Chem. Soc. 99: 4123-4130. PMID: 864107
3. Mulherkar, L., et al. 1978. Indian J. Exp. Biol. 16: 430-434. PMID: 680852
4. Ghaskadbi, S. and Mulherkar, L. 1982. Exp. Cell Biol. 50: 155-161. PMID: 7095250
5. Cooper, J.A., 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229
6. Natarajan, P., et al. 2000. Platelets. 11: 467-476. PMID: 11177446

Usage :
Cytochalasins are regarded as highly toxic and possible teratogens. Handle in a manner to avoid/minimize direct body contact and inhalation.
Physical State :
Solid
Derived From :
Phomopsis sp.
Solubility :
Soluble in ethanol, DMSO, DMF, and methanol. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
254-258° C
Boiling Point :
676.49° C at 760 mmHg (Predicted)
Density :
1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HA5306000
PubChem CID :
16211932
MDL Number :
MFCD00010539
Beilstein Registry :
1632647
SMILES :
CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O

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Cytochalasin H  Product Citations

See how others have used Cytochalasin H. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 18661133  Stoeger, SM. et al. 2009. Cancer Chemother. Pharmacol. 63: 807-818.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yi Yi, JM. et al. (PubMed 26027832) found that EEGS and its active constituent, Cytochalasin H, have anti-angiogenic activity in vitro and in vivo via suppression of endothelial cell functions. EEGS and cytochalasin H were observed to efficiently inhibit tumor growth in an in ovo xenograft model without significant toxicity. -SCBT Publication Review
Date published: 2015-04-01
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