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Cytidine 5′-diphosphocholine, Sodium Salt (CDP-choline) (CAS 33818-15-4)

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Alternate Names:
Citicoline Sodium
Application:
Cytidine 5′-diphosphocholine, Sodium Salt (CDP-choline) is a PLA2 inhibitor and acetylcholine receptor inducer
CAS Number:
33818-15-4
Purity:
≥98%
Molecular Weight:
510.31
Molecular Formula:
C14H25N4O11P2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cytidine 5′-diphosphocholine (CDP-choline) plays a role in the biosynthesis of phosphatidylcholine, a key component of cell membranes, demonstrating a significant capacity to influence cellular mechanisms and neurochemical dynamics within research applications, particularly concerning neural tissue integrity and neurotransmitter modulation. Its ability to elevate the densities of dopamine and acetylcholine receptors, which suggests a potential for modulating neurotransmitter systems and enhancing synaptic transmission efficiency. Beyond its direct impact on cell membrane composition and neurotransmitter receptor regulation, CDP-choline has been implicated in the upregulation of cholinergic activity, both within neural circuits and in non-neural tissues, pointing to a broad spectrum of biochemical influence. Intriguingly, research further indicates that CDP-choline may augment the stimulated release of pivotal hormones such as thyroid-stimulating hormone, growth hormone, and luteinizing hormone, thereby hinting at its utility in studying endocrine system responses and neuroendocrine interactions.


Cytidine 5′-diphosphocholine, Sodium Salt (CDP-choline) (CAS 33818-15-4) References

  1. Blood metabolism of [methyl-11C]choline; implications for in vivo imaging with positron emission tomography.  |  Roivainen, A., et al. 2000. Eur J Nucl Med. 27: 25-32. PMID: 10654143
  2. CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement.  |  Cavun, S. and Savci, V. 2004. Fundam Clin Pharmacol. 18: 513-23. PMID: 15482372
  3. Activation of osmolyte efflux from cultured renal papillary epithelial cells.  |  Furlong, TJ., et al. 1991. J Membr Biol. 123: 269-77. PMID: 1744906
  4. Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice.  |  Giménez, R., et al. 1991. Br J Pharmacol. 104: 575-8. PMID: 1839138
  5. Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia.  |  Yilmaz, Z., et al. 2010. Blood Coagul Fibrinolysis. 21: 339-48. PMID: 20410813
  6. Effects of CDP-choline on phospholipase A2 and cholinephosphotransferase activities following a cryogenic brain injury in the rabbit.  |  Arrigoni, E., et al. 1987. Biochem Pharmacol. 36: 3697-700. PMID: 2823830
  7. A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML.  |  Drenberg, CD., et al. 2019. Nat Commun. 10: 2189. PMID: 31097698
  8. Developmental changes in enzyme activities in fetal and neonatal rabbit lung. Cytidylyltransferase, cholinephosphotransferase, phospholipases A1 and A2, beta-galactosidase, and beta-glucuronidase.  |  Heath, MF. and Jacobson, W. 1984. Pediatr Res. 18: 395-401. PMID: 6328405
  9. Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats.  |  Onal, MZ., et al. 1997. Stroke. 28: 1060-5. PMID: 9158650

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cytidine 5′-diphosphocholine, Sodium Salt (CDP-choline), 100 mg

sc-200713
100 mg
$52.00

Cytidine 5′-diphosphocholine, Sodium Salt (CDP-choline), 1 g

sc-200713A
1 g
$166.00