Date published: 2025-10-19

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Cytarabine 5′-Monophosphate (CAS 7075-11-8)

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Alternate Names:
4-Amino-1-(5-O-phosphono-β-D-arabinofuranosyl)-2(1H)-pyrimidinone; Cytosine-β-D-arabinofuranoside-5′-monophosphoric Acid
Application:
Cytarabine 5′-Monophosphate is A potent cytotoxic-antiviral nucleoside derived from Cytarabine.
CAS Number:
7075-11-8
Molecular Weight:
323.20
Molecular Formula:
C9H14N3O8P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cytarabine 5′-Monophosphate, potent cytotoxic-antiviral nucleoside derived from Cytarabine. The addition of a phosphate group at the 5′ position transforms cytarabine into its monophosphate form, which plays a role in its biochemical interactions and mechanisms within cellular processes. As a nucleoside analog, cytarabine 5′-monophosphate and its further phosphorylated forms can be incorporated into DNA during the replication process. This incorporation leads to chain termination due to the inability of DNA polymerases to add further nucleotides, effectively halting DNA synthesis and thereby blocking cell division. Studies may involve examining the enzymes responsible for the phosphorylation of cytarabine, such as nucleoside kinases, which are for its activation.


Cytarabine 5′-Monophosphate (CAS 7075-11-8) References

  1. Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug.  |  Tobias, SC. and Borch, RF. 2004. Mol Pharm. 1: 112-6. PMID: 15832507
  2. A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy.  |  Kim, JS., et al. 2012. Mol Vis. 18: 1907-17. PMID: 22876115
  3. Improving nucleoside analogs via lipid conjugation: Is fatter any better?  |  Alexander, P., et al. 2016. Crit Rev Oncol Hematol. 100: 46-56. PMID: 26829896
  4. The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.  |  Alexander, PM., et al. 2017. PLoS One. 12: e0179798. PMID: 28644853
  5. Identifying Candidates for Breast Cancer Using Interactions of Chemicals and Proteins.  |  Lu, J., et al. 2017. Comb Chem High Throughput Screen.. PMID: 29165068
  6. Cytarabine and dexamethasone-PAMAM dendrimer di-conjugate sensitizes human acute myeloid leukemia cells to apoptotic cell death  |  Wróbel, K., Deręgowska, A., Betlej, G., Walczak, M., Wnuk, M., Lewińska, A., & Wołowiec, S. 2023. Journal of Drug Delivery Science and Technology. 81: 104242.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cytarabine 5′-Monophosphate, 50 mg

sc-214789A
50 mg
$242.00

Cytarabine 5′-Monophosphate, 100 mg

sc-214789
100 mg
$353.00

Cytarabine 5′-Monophosphate, 250 mg

sc-214789B
250 mg
$765.00

Cytarabine 5′-Monophosphate, 500 mg

sc-214789C
500 mg
$1123.00

Cytarabine 5′-Monophosphate, 1 g

sc-214789D
1 g
$1587.00

Cytarabine 5′-Monophosphate, 10 g

sc-214789E
10 g
$7656.00