Cytarabine-13C3
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Cytarabine-13C3 is a labeled form of cytarabine, a pyrimidine analog that inhibits DNA synthesis. It functions by being incorporated into the DNA of rapidly dividing cells, leading to chain termination and inhibition of DNA polymerase. Cytarabine-13c3 disrupts the synthesis of DNA, preventing the replication of cancer cells and ultimately leading to cell death. Cytarabine-13C3 acts as a metabolic tracer in studies involving the metabolism and pharmacokinetics of cytarabine. Its mechanism of action involves interfering with the normal function of DNA, which may be useful for investigating the molecular mechanisms of DNA synthesis and replication. In experimental applications, Cytarabine-13C3 is utilized to study the effects of cytarabine on cellular processes and to track the metabolic fate within cells. Its labeled carbon atoms allow for precise tracking of the compound′s metabolic pathways and its interactions with cellular components.
Cytarabine-13C3 References
- Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma. | Kunou, S., et al. 2021. Oncogene. 40: 3989-4003. PMID: 33994542
- IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia. | Vervoort, BMT., et al. 2024. Haematologica.. PMID: 38841778
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytarabine-13C3, 2.5 mg | sc-217994 | 2.5 mg | $1224.00 |