cystatin E/M Antibody (E/M29): sc-73881

Cystatin E/M Antibody (E/M29) is a mouse monoclonal IgG2b antibody that detects cystatin E/M protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-cystatin E/M antibody (E/M29) is available as the non-conjugated format. Cystatin E/M, also known as CST6, plays a crucial role in regulating proteolytic activity in extracellular environments, particularly by inhibiting cysteine proteases such as cathepsins. This inhibition is vital for maintaining tissue homeostasis and preventing excessive proteolysis, which can lead to various pathological conditions, including cancer and inflammatory diseases. Cystatin E/M is predominantly found in extracellular spaces, where CST6 helps modulate the activity of proteases involved in tissue remodeling and immune responses. By controlling these proteolytic processes, cystatin E/M contributes to the regulation of cellular signaling pathways and the maintenance of extracellular matrix integrity. The cystatin superfamily, to which cystatin E/M belongs, is known for its diverse roles in various biological processes, including inflammation, apoptosis, and tissue repair, making CST6 an important target for research in both basic and clinical settings.

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cystatin E/M Antibody (E/M29) References:

1. Involvement of cystatin C in oxidative stress-induced apoptosis of cultured rat CNS neurons.  |  Nishio, C., et al. 2000. Brain Res. 873: 252-62. PMID: 10930551
2. Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping.  |  Janowski, R., et al. 2001. Nat Struct Biol. 8: 316-20. PMID: 11276250
3. Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type.  |  Calero, M., et al. 2001. J Neurochem. 77: 628-37. PMID: 11299325
4. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing.  |  Manoury, B., et al. 2001. Curr Biol. 11: 447-51. PMID: 11301256
5. Cystatin C is an independent predictor of fasting and post-methionine load total homocysteine concentrations among stable renal transplant recipients.  |  Aras O, ., et al. 2001. Clin Chem. 47: 1263-8. PMID: 11427458
6. Cystatins.  |  Abrahamson, M., et al. 2003. Biochem Soc Symp. 179-99. PMID: 14587292
7. Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.  |  Saitoh, E., et al. 1988. Biol Chem Hoppe Seyler. 369 Suppl: 191-7. PMID: 3202964

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cystatin E/M Antibody (E/M29) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-cystatin E/M Antibody (E/M29) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cystatin E/M Antibody (E/M29) Specifications

Alternate Product Name: cystatin E/M

Product Clone Name: E/M29

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 29-149

Epitope Target: cystatin E/M

Epitope Species: human

Product Reactivity/Detection: cystatin E/M

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for cystatin E/M Antibody (E/M29): L: Azide-Free