cystatin C Antibody (Cyst-13): sc-51857
- cystatin C Antibody (Cyst-13) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against full length cystatin C purified from human urine
- recommended for detection of cystatin C of human origin by WB, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for cystatin C Antibody (Cyst-13). This work is in progress.
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Cystatin C Antibody (Cyst-13) is a mouse monoclonal IgG1 antibody that detects cystatin C in human samples through applications such as western blotting (WB), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cystatin C is a crucial cysteine protease inhibitor that plays a significant role in regulating proteolytic activity in extracellular environments, thereby maintaining cellular homeostasis and preventing excessive protease activity that could lead to tissue damage. Anti-cystatin C antibody (Cyst-13) recognizes a protein primarily secreted by various cell types, including neurons and glial cells, and expression is closely linked to kidney function and glomerular filtration rate, making cystatin C a valuable biomarker for renal health. Notably, cystatin C can form amyloid aggregates, particularly in the presence of mutations in its gene, which are associated with hereditary cerebral amyloid angiopathy and increased risk of cerebral hemorrhage. Cystatin C (Cyst-13) monoclonal antibody enables research into cystatin C′s ability to form dimers under pathological conditions, highlighting cystatin C′s importance in cellular stress responses, as oxidative stress can enhance expression, potentially influencing apoptotic pathways in neuronal cells.
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cystatin C Antibody (Cyst-13) References:
- Assessment of cystatin C and cystatin C-based GFR formulas in reflux nephropathy. | Yavuz, S., et al. 2014. J Pediatr Urol. 10: 262-7. PMID: 24128877
- Cystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate. | Ebert, N., et al. 2016. Clin Chim Acta. 456: 115-121. PMID: 26947968
- Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care. | Helmersson-Karlqvist, J., et al. 2022. Heart. 108: 279-284. PMID: 33795382
- Elevated Serum Cystatin C and Decreased Cathepsin S/Cystatin C Ratio Are Associated with Severe Peripheral Arterial Disease and Polyvascular Involvement. | Nagy, EE., et al. 2022. Diagnostics (Basel). 12: PMID: 35453881
- Serum Cystatin C is Associated with Depression After Intracerebral Hemorrhage. | Zhu, L., et al. 2023. Neuropsychiatr Dis Treat. 19: 1117-1126. PMID: 37188225
- The potential of cystatin C as a predictive biomarker in pulmonary hypertension. | Duan, A., et al. 2023. BMC Pulm Med. 23: 311. PMID: 37633906
- Modification of Association of Cystatin C With Kidney and Cardiovascular Outcomes by Obesity. | Chen, DC., et al. 2024. Am J Kidney Dis. 83: 489-496.e1. PMID: 37866793
- Role of cystatin C levels as an inflammatory marker in predicting endometriosis. | Kılıçkıran, H., et al. 2023. Rev Assoc Med Bras (1992). 69: e20230613. PMID: 38055453
- Cystatin C: immunoregulation role in macrophages infected with Porphyromonas gingivalis. | Blancas-Luciano, BE., et al. 2024. PeerJ. 12: e17252. PMID: 38708345
- Associations of Serum Cystatin C, DNAm Cystatin C, Renal Function, and Mortality in U.S. Adults. | Fang, YW., et al. 2024. Life (Basel). 15: PMID: 39859953
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cystatin C Antibody (Cyst-13) | sc-51857 | 100 µg/ml | $322.00 |