cystatin C Activators
The chemical class of cystatin C activators encompasses a diverse array of compounds, each contributing to the modulation of cellular pathways that ultimately lead to the enhanced expression of cystatin C. These activators act through both direct and indirect mechanisms, showcasing the intricate ways by which cellular processes can be influenced to support the functionality of cystatin C. Resveratrol, a polyphenol found in red wine, activates AMP-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis. This activation indirectly upregulates cystatin C expression by promoting cellular energy balance, establishing a direct link between metabolic pathways and cystatin C activation. Curcumin, a natural compound from turmeric, activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This activation induces the expression of cystatin C by binding to its promoter region, providing a direct molecular mechanism for the activation of cystatin C through dietary components.
Sulforaphane, a compound found in cruciferous vegetables, also activates the Nrf2 pathway, leading to the transcriptional upregulation of cystatin C. This demonstrates how specific dietary choices can modulate cystatin C expression through the manipulation of cellular stress response pathways. Other compounds such as Butyrate, Luteolin, and α-Lipoic Acid exert their effects through various pathways, including modulation of histone acetylation and activation of AMPK, highlighting the multifaceted nature of cystatin C regulation. In addition to these, EGCG, Rosmarinic Acid, Oleanolic Acid, Carnosic Acid, Ginkgolide B, and Quercetin each activate specific pathways, such as AMPK, Nrf2, or NF-κB, contributing to the orchestration of cellular responses that culminate in the upregulation of cystatin C.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenol that activates AMP-activated protein kinase (AMPK), a key cellular energy sensor. Through AMPK activation, Resveratrol indirectly upregulates cystatin C expression, modulating cellular energy levels and supporting its function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural compound from turmeric, activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Nrf2 activation induces the expression of cystatin C by binding to its promoter region, providing a direct mechanism for the enhancement of cystatin C levels. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, a master regulator of antioxidant responses. Nrf2 activation by Sulforaphane leads to the transcriptional upregulation of cystatin C, establishing a direct link between Sulforaphane-induced pathways and increased cystatin C expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid, modulates histone acetylation and activates histone deacetylase (HDAC) inhibitors. This epigenetic modulation indirectly enhances cystatin C expression by affecting chromatin structure, providing a distinct mechanism for the activation of cystatin C. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin, a flavonoid, activates the Nrf2 pathway, similar to Curcumin and Sulforaphane. By promoting Nrf2-mediated gene expression, Luteolin directly contributes to the activation of cystatin C, ensuring its increased expression in response to cellular stressors. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin found in green tea, activates the 5' adenosine monophosphate-activated protein kinase (AMPK) pathway. By modulating AMPK, EGCG indirectly upregulates cystatin C expression, establishing a connection between green tea consumption and cystatin C activation. | ||||||
Rosmarinic Acid | 20283-92-5 | sc-202796 sc-202796A | 10 mg 50 mg | $57.00 $107.00 | 4 | |
Rosmarinic Acid, a polyphenol found in herbs like rosemary, activates Nrf2, similar to other polyphenols. Nrf2 activation by Rosmarinic Acid leads to the transcriptional upregulation of cystatin C, establishing it as a direct activator of cystatin C expression within cellular environments. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
Oleanolic Acid, a natural triterpenoid, activates Nrf2 and induces the expression of antioxidant genes. Through Nrf2 activation, Oleanolic Acid directly upregulates cystatin C expression, contributing to cellular defense mechanisms and ensuring the maintenance of cystatin C function. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic Acid, a potent antioxidant, activates the AMPK pathway. Through AMPK activation, α-Lipoic Acid indirectly upregulates cystatin C expression, connecting its antioxidant properties to the modulation of cellular energy pathways and the enhancement of cystatin C levels. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $60.00 $165.00 | 6 | |
Carnosic Acid, a phenolic diterpene, activates Nrf2 and induces the expression of antioxidant genes. Nrf2 activation by Carnosic Acid leads to the transcriptional upregulation of cystatin C, establishing it as a direct activator of cystatin C expression within cellular environments. | ||||||