cystatin C Antibody (C-27): sc-73878

cystatin C Antibody (C-27) is a mouse monoclonal IgG2b antibody that detects cystatin C in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Cystatin C is a crucial cysteine protease inhibitor that plays a significant role in regulating proteolytic activity in extracellular environments, making it vital for maintaining cellular homeostasis and preventing tissue damage. Cystatin C is primarily secreted by various cell types and forms a two-fold symmetric dimer, which is essential for modulating cysteine protease activity and influencing the expression of class II major histocompatibility complex molecules. Cystatin C serves as a reliable biomarker for kidney function and glomerular filtration rate, with expression levels providing insights into renal health. Mutations in the cystatin C gene can lead to protein aggregates, which are associated with hereditary cerebral amyloid angiopathy and increased risk of cerebral hemorrhage. While both wild-type and mutant forms of cystatin C can form inactive dimers, the mutant variant tends to dimerize at lower concentrations and is more vulnerable to degradation by serine proteases, potentially promoting aggregation. In neuronal cells, oxidative stress enhances cystatin C expression, which may play a role in regulating apoptosis, further underscoring cystatin C′s importance in various physiological and pathological processes. Anti-cystatin C antibody (C-27) is an invaluable tool for researchers investigating the multifaceted roles of cystatin C in health and disease.

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cystatin C Antibody (C-27) References:

1. Cystatin C expression is associated with granule cell dispersion in epilepsy.  |  Pirttilä, TJ., et al. 2005. Ann Neurol. 58: 211-23. PMID: 16049933
2. Cystatin C is associated with inflammation but not atherosclerosis in systemic lupus erythematosus.  |  Lertnawapan, R., et al. 2012. Lupus. 21: 279-87. PMID: 22072023
3. Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.  |  Wallin, H., et al. 2013. J Biol Chem. 288: 17019-17029. PMID: 23629651
4. Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality.  |  O'Seaghdha, CM., et al. 2014. Am J Kidney Dis. 63: 16-22. PMID: 23932088
5. Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds.  |  Oh, MY., et al. 2014. BMC Neurol. 14: 127. PMID: 24925313
6. Parenchymal cystatin C focal deposits and glial scar formation around brain arteries in Hereditary Cystatin C Amyloid Angiopathy.  |  Osk Snorradottir, A., et al. 2015. Brain Res. 1622: 149-62. PMID: 26115583
7. Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.  |  Yan, Y., et al. 2015. Int J Clin Exp Pathol. 8: 10102-11. PMID: 26617717
8. Cystatin C as a Marker of Progressing Cardiovascular Events during Coronary Heart Disease.  |  Gevorgyan, MM., et al. 2017. Bull Exp Biol Med. 162: 421-424. PMID: 28239794
9. Cystatin C-Adiponectin Complex in Plasma Associates with Coronary Plaque Instability.  |  Matsumoto, A., et al. 2017. J Atheroscler Thromb. 24: 970-979. PMID: 28321013
10. Discordance between creatinine and cystatin C in patients with leukemia.  |  Vaqueiro Graña, M., et al. 2023. An Pediatr (Engl Ed). 99: 203-205. PMID: 37541852

The preferred cystatin C antibody is cystatin C Antibody (A-10): sc-515732.