Molecular structure of Cysmethynil, CAS Number: 851636-83-4
Cysmethynil (CAS 851636-83-4)
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Alternate Names:
Icmt Inhibitor
Application:
Cysmethynil is a ICMT inhibitor
CAS Number:
851636-83-4
Molecular Weight:
376.53
Molecular Formula:
C25H32N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cysmethynil is classified as an ICMT inhibitor, exerting its effects by impeding the activity of enzymes for synthesizing specific proteins and hindering the binding of certain hormones to their respective receptors. Furthermore, cysmethynil has demonstrated the ability to impede the activity of select enzymes involved in the degradation of nucleic acids and proteins. By acting on these various targets, cysmethynil plays a multifaceted role in regulating cellular processes, ultimately impacting protein synthesis, hormonal signaling, and the breakdown of nucleic acids and proteins.
Cysmethynil (CAS 851636-83-4) References
- Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. | Svensson, AW., et al. 2006. Methods Enzymol. 407: 144-59. PMID: 16757321
- A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma. | Wang, M., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 553-7. PMID: 19157999
- Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. | Cushman, I. and Casey, PJ. 2009. J Biol Chem. 284: 27964-27973. PMID: 19651782
- Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth. | Wang, M., et al. 2010. Oncogene. 29: 4959-70. PMID: 20622895
- Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). | Ramanujulu, PM., et al. 2013. Eur J Med Chem. 63: 378-86. PMID: 23514631
- An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. | Lau, HY., et al. 2014. Cancer Biol Ther. 15: 1280-91. PMID: 24971579
- Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents. | Yang, WS., et al. 2017. Amino Acids. 49: 1469-1485. PMID: 28631011
- Isoprenylcysteine carboxylmethyltransferase regulates ovarian cancer cell response to chemotherapy and Ras activation. | Liu, Q., et al. 2018. Biochem Biophys Res Commun. 501: 556-562. PMID: 29746868
- Isoprenylcysteine carboxyl methyltransferase inhibitors exerts anti-inflammatory activity. | Yang, WS., et al. 2020. Biochem Pharmacol. 182: 114219. PMID: 32931773
- An In Vivo Inflammatory Loop Potentiates KRAS Blockade. | Arendt, KAM., et al. 2022. Biomedicines. 10: PMID: 35327394
- Catalytic Cyanation of C-N Bonds with CO2/NH3. | Yan, F., et al. 2022. JACS Au. 2: 2522-2528. PMID: 36465537
Inhibitor of:
RGL4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cysmethynil, 5 mg | sc-500804 | 5 mg | $133.00 | |||
Cysmethynil, 10 mg | sc-500804A | 10 mg | $253.00 |