Molecular structure of CyPPA, CAS Number: 73029-73-9
CyPPA (CAS 73029-73-9)
Alternate Names:
N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
Application:
CyPPA is an activator of small conductance Ca2+ activated K+ channels
CAS Number:
73029-73-9
Molecular Weight:
285.39
Molecular Formula:
C16H23N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
CyPPA is an activator of small conductance Ca2+-activated K+ channels. Selective for SK2 and SK3 channels, no selectivity for SK1 and IK channels.
CyPPA (CAS 73029-73-9) References
- Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. | Hougaard, C., et al. 2007. Br J Pharmacol. 151: 655-65. PMID: 17486140
- Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. | Dalsgaard, T., et al. 2010. Br J Pharmacol. 160: 1496-508. PMID: 20590639
- CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. | Skarra, DV., et al. 2011. Am J Physiol Cell Physiol. 301: C1027-35. PMID: 21795518
- CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. | Herrik, KF., et al. 2012. Front Pharmacol. 3: 11. PMID: 22347859
- Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. | Dolga, AM., et al. 2012. Glia. 60: 2050-64. PMID: 23002008
- Concomitant SK current activation and sodium current inhibition cause J wave syndrome. | Chen, M., et al. 2018. JCI Insight. 3: PMID: 30429367
- The ion channel activator CyPPA inhibits melanogenesis via the GSK3β/β-catenin pathway. | Noh, TK., et al. 2019. Chem Biol Interact. 300: 1-7. PMID: 30597128
- Diadenosine tetraphosphate activates P2Y1 receptors that cause smooth muscle relaxation in the mouse colon. | Paquola, A., et al. 2019. Eur J Pharmacol. 855: 160-166. PMID: 31063775
- Subtype-selective positive modulation of KCa 2 channels depends on the HA/HB helices. | Nam, YW., et al. 2022. Br J Pharmacol. 179: 460-472. PMID: 34458981
- Augmented KCa2.3 Channel Feedback Regulation of Oxytocin Stimulated Uterine Strips from Nonpregnant Mice. | Zak, M., et al. 2021. Int J Mol Sci. 22: PMID: 34948381
- Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. | El-Sayed, NS., et al. 2022. J Med Chem. 65: 303-322. PMID: 34962403
- Electrophysiological Studies Support Utility of Positive Modulators of SK Channels for the Treatment of Spinocerebellar Ataxia Type 2. | Egorova, PA. and Bezprozvanny, IB. 2022. Cerebellum. 21: 742-749. PMID: 34978024
- SK-Channel Activation Alters Peripheral Metabolic Pathways in Mice, but Not Lipopolysaccharide-Induced Fever or Inflammation. | Bredehöft, J., et al. 2022. J Inflamm Res. 15: 509-531. PMID: 35115803
Activator of:
KCNN2, SK3, and TWIK-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CyPPA, 10 mg | sc-205281 | 10 mg | $145.00 | |||
CyPPA, 50 mg | sc-205281A | 50 mg | $645.00 |