CYP4F11 Antibody (F21 P6 F5): sc-53619

CYP4F11 Antibody (F21 P6 F5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CYP4F11 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-CYP4F11 antibody (F21 P6 F5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CYP4F11, an isoform of the cytochrome P450 4F family, plays a crucial role in the metabolism of endogenous eicosanoids and certain therapeutic drugs, highlighting its importance in pharmacokinetics and drug interactions. CYP4F11 is predominantly expressed in the human liver, with additional expression in the kidney, heart, and skeletal muscle, which underscores its significance in various physiological processes and potential implications in drug metabolism across different tissues. With a structure comprising 524 amino acids, CYP4F11 shares substantial sequence identity with other CYP4F isoforms, such as CYP4F2, CYP4F3, and CYP4F8, suggesting functional similarities and interactions within the cytochrome P450 enzyme system. CYP4F11′s ability to metabolize large molecules, including erythromycin, further emphasizes its relevance in clinical settings, making CYP4F11 (F21 P6 F5) antibody an essential tool for researchers studying drug metabolism and the physiological roles of cytochrome P450 enzymes.

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CYP4F11 Antibody (F21 P6 F5) References:

1. Purification and characterization of recombinant rat hepatic CYP4F1.  |  Kikuta, Y., et al. 1999. Arch Biochem Biophys. 369: 193-6. PMID: 10486137
2. A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization.  |  Cui, X., et al. 2000. Genomics. 68: 161-6. PMID: 10964514
3. cDna cloning and expression of CYP4F12, a novel human cytochrome P450.  |  Bylund, J., et al. 2001. Biochem Biophys Res Commun. 280: 892-7. PMID: 11162607
4. Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.  |  Kalsotra, A., et al. 2004. Toxicol Appl Pharmacol. 199: 295-304. PMID: 15364545
5. Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.  |  Kumarakulasingham, M., et al. 2005. Clin Cancer Res. 11: 3758-65. PMID: 15897573

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CYP4F11 Antibody (F21 P6 F5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-CYP4F11 Antibody (F21 P6 F5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CYP4F11 Antibody (F21 P6 F5) Specifications

Alternate Product Name: CYP4F11

Product Clone Name: F21 P6 F5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CYP4F11

Epitope Species: human

Product Reactivity/Detection: CYP4F11

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for CYP4F11 Antibody (F21 P6 F5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin