CYP2W1 Antibody (C-7): sc-374426
- CYP2W1 Antibody (C-7) is a mouse monoclonal IgG1 κ CYP2W1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 121-295 mapping within an internal region of CYP2W1 of human origin
- CYP2W1 Antibody (C-7) is recommended for detection of CYP2W1 of human origin by WB, IP, IF and ELISA
- Anti-CYP2W1 Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CYP2W1 Antibody (C-7) for WB applications. These reagents are now offered in bundles with CYP2W1 Antibody (C-7) (see ordering information below).
CYP2W1 Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CYP2W1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CYP2W1 antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CYP2W1, consisting of 490 amino acids, is a member of the cytochrome P450 family, which plays a crucial role in metabolizing diverse endogenous and xenobiotic compounds. Notably, CYP2W1 is recognized as a tumor-specific isoform of cytochrome P450 conserved across vertebrates, making CYP2W1 a promising target for cancer therapeutics. CYP2W1 is primarily located in the endoplasmic reticulum of cells, where CYP2W1 facilitates the oxidation of various substrates, including arachidonic acid and indole. Localization in the endoplasmic reticulum allows efficient interaction with other metabolic enzymes and substrates, thereby influencing metabolic pathways critical for cellular function and drug metabolism. CYP2W1′s ability to metabolize compounds involved in signaling pathways further underscores CYP2W1′s potential importance in cancer biology and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CYP2W1 Antibody (C-7) References:
- Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis. | Kumarakulasingham, M., et al. 2005. Clin Cancer Res. 11: 3758-65. PMID: 15897573
- Novel extrahepatic cytochrome P450s. | Karlgren, M., et al. 2005. Toxicol Appl Pharmacol. 207: 57-61. PMID: 15987645
- The human genome project and novel aspects of cytochrome P450 research. | Ingelman-Sundberg, M. 2005. Toxicol Appl Pharmacol. 207: 52-6. PMID: 15993453
- Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. | Karlgren, M., et al. 2006. Biochem Biophys Res Commun. 341: 451-8. PMID: 16426568
- Enzymatic properties of human CYP2W1 expressed in Escherichia coli. | Yoshioka, H., et al. 2006. Biochem Biophys Res Commun. 345: 169-74. PMID: 16677611
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP2W1 Antibody (C-7) | sc-374426 | 200 µg/ml | $322.00 | |||
CYP2W1 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-529743 | 200 µg Ab; 10 µg BP | $361.00 | |||
CYP2W1 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-522735 | 200 µg Ab, 40 µg BP | $361.00 | |||
CYP2W1 Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-543665 | 200 µg Ab; 20 µg BP | $361.00 | |||
CYP2W1 Antibody (C-7) AC | sc-374426 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CYP2W1 Antibody (C-7) HRP | sc-374426 HRP | 200 µg/ml | $322.00 | |||
CYP2W1 Antibody (C-7) FITC | sc-374426 FITC | 200 µg/ml | $336.00 | |||
CYP2W1 Antibody (C-7) PE | sc-374426 PE | 200 µg/ml | $349.00 | |||
CYP2W1 Antibody (C-7) Alexa Fluor® 488 | sc-374426 AF488 | 200 µg/ml | $364.00 | |||
CYP2W1 Antibody (C-7) Alexa Fluor® 546 | sc-374426 AF546 | 200 µg/ml | $364.00 | |||
CYP2W1 Antibody (C-7) Alexa Fluor® 594 | sc-374426 AF594 | 200 µg/ml | $364.00 | |||
CYP2W1 Antibody (C-7) Alexa Fluor® 647 | sc-374426 AF647 | 200 µg/ml | $364.00 | |||
CYP2W1 Antibody (C-7) Alexa Fluor® 680 | sc-374426 AF680 | 200 µg/ml | $364.00 | |||
CYP2W1 Antibody (C-7) Alexa Fluor® 790 | sc-374426 AF790 | 200 µg/ml | $364.00 |