CYP2S1 Antibody (G-1): sc-365806

CYP2S1 Antibody (G-1) is a mouse monoclonal IgM antibody that detects CYP2S1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CYP2S1 antibody (G-1) is available in a non-conjugated form, allowing for versatile experimental use. CYP2S1, a member of the cytochrome P450 family, plays a crucial role in the metabolism of various endogenous and exogenous compounds, including retinoic acid and aromatic hydrocarbons. CYP2S1 is predominantly located in the endoplasmic reticulum of epithelial cells found in extrahepatic tissues, such as the respiratory and gastrointestinal tracts, as well as the skin, which are often exposed to xenobiotics. Such localization enables efficient metabolism of drugs and environmental toxins, thereby influencing pharmacokinetics and toxicology. CYP2S1 is implicated in the metabolism of topical medications and has a role in the response to photochemotherapy in conditions like psoriasis. CYP2S1 expression can be induced by dioxin, with regulation mediated by the aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator, highlighting its importance in xenobiotic metabolism and potential therapeutic applications.

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CYP2S1 Antibody (G-1) References:

1. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1).  |  Rylander, T., et al. 2001. Biochem Biophys Res Commun. 281: 529-35. PMID: 11181079
2. Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.  |  Smith, G., et al. 2003. Lancet. 361: 1336-43. PMID: 12711469
3. Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population.  |  Saarikoski, ST., et al. 2004. Mutat Res. 554: 267-77. PMID: 15450424
4. Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues.  |  Choudhary, D., et al. 2005. Arch Biochem Biophys. 436: 50-61. PMID: 15752708
5. Localization of cytochrome P450 CYP2S1 expression in human tissues by in situ hybridization and immunohistochemistry.  |  Saarikoski, ST., et al. 2005. J Histochem Cytochem. 53: 549-56. PMID: 15872048
6. Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.  |  Kumarakulasingham, M., et al. 2005. Clin Cancer Res. 11: 3758-65. PMID: 15897573
7. Novel extrahepatic cytochrome P450s.  |  Karlgren, M., et al. 2005. Toxicol Appl Pharmacol. 207: 57-61. PMID: 15987645
8. The human genome project and novel aspects of cytochrome P450 research.  |  Ingelman-Sundberg, M. 2005. Toxicol Appl Pharmacol. 207: 52-6. PMID: 15993453
9. CYP2S1: a short review.  |  Saarikoski, ST., et al. 2005. Toxicol Appl Pharmacol. 207: 62-9. PMID: 16054184

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CYP2S1 Antibody (G-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CYP2S1 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CYP2S1 Antibody (G-1) Specifications

Alternate Product Name: CYP2S1

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 473-504

Epitope Target: CYP2S1

Epitope Species: human

Product Reactivity/Detection: CYP2S1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CYP2S1 Antibody (G-1): P: Blocking Peptide