CYP26B1 Antibody (2G7): sc-293493
- CYP26B1 Antibody (2G7) is a mouse monoclonal IgG2a κ CYP26B1 antibody provided at 100 µg/ml
- raised against amino acids 131-230 representing partial length CYP26B1 of human origin
- recommended for detection of CYP26B1 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CYP26B1 Antibody (2G7). This work is in progress.
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CYP26B1 Antibody (2G7) is a mouse monoclonal IgG2a kappa light chain antibody that detects CYP26B1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CYP26B1 antibody (2G7) is available as a non-conjugated format. CYP26B1, also known as cytochrome P450 retinoic acid-inactivating 2 (P450RAI2), plays a crucial role in retinoic acid metabolism, a derivative of vitamin A essential for various biological processes, including embryonic development, cell differentiation, and tissue homeostasis. CYP26B1 is primarily localized to endoplasmic reticulum and microsome membranes, with significant expression in brain, particularly in cerebellum and pons, highlighting CYP26B1′s importance in neurological functions. CYP26B1 is responsible for specific inactivation of all-trans-retinoic acid, converting CYP26B1 into several hydroxylated forms, which is vital for maintaining appropriate retinoic acid levels in tissues and preventing potential toxic effects from accumulation. CYP26B1′s ability to regulate retinoic acid levels underscores CYP26B1′s significance in developmental biology and potential implications in various diseases, including cancer and neurodegenerative disorders.
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CYP26B1 Antibody (2G7) References:
- A second CYP26 P450 in humans and zebrafish: CYP26B1. | Nelson, DR. 1999. Arch Biochem Biophys. 371: 345-7. PMID: 10545224
- Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. | White, JA., et al. 2000. Proc Natl Acad Sci U S A. 97: 6403-8. PMID: 10823918
- Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues. | Trofimova-Griffin, ME. and Juchau, MR. 2002. Brain Res Dev Brain Res. 136: 175-8. PMID: 12101034
- A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid. | Taimi, M., et al. 2004. J Biol Chem. 279: 77-85. PMID: 14532297
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. | Nelson, DR., et al. 2004. Pharmacogenetics. 14: 1-18. PMID: 15128046
- Retinoid signaling determines germ cell fate in mice. | Bowles, J., et al. 2006. Science. 312: 596-600. PMID: 16574820
- Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. | Rat, E., et al. 2006. Birth Defects Res A Clin Mol Teratol. 76: 491-8. PMID: 16933217
- Positive association between ALDH1A2 and schizophrenia in the Chinese population. | Wan, C., et al. 2009. Prog Neuropsychopharmacol Biol Psychiatry. 33: 1491-5. PMID: 19703508
- A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation. | Tay, S., et al. 2010. Mol Pharmacol. 77: 218-27. PMID: 19884280
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP26B1 Antibody (2G7) | sc-293493 | 100 µg/ml | $322.00 |