Date published: 2026-4-28

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Cylindrospermopsin (CAS 143545-90-8)

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Alternate Names:
(2aS,3R,4S,5aS,7R)-7-[(S)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl]-3-methyl-2a,3,4,5,5a,6,7,8-octahydro-2H-1,8,8b-triazaacenaphthylen-4-yl hydrogen sulfate
Application:
Cylindrospermopsin is a cyanotoxin inhibitor of protein synthesis
CAS Number:
143545-90-8
Purity:
≥95%
Molecular Weight:
415.4
Molecular Formula:
C15H21N5O7S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cylindrospermopsin is a cyanotoxin found in various freshwater cyanobacteria, including species such as Cylindrospermopsis raciborskii. It is an alkaloid associated with waterborne hazards and is a subject of investigation in environmental toxicology. Studies focus on its mode of action as an inhibitor of protein synthesis, which is a concern for water safety and public health. In aquatic ecosystems, research on Cylindrospermopsin includes monitoring its presence and understanding the conditions that favor cyanobacterial blooms that produce this toxin. Additionally, researchers use Cylindrospermopsin to study its biodegradation by natural water communities or through water treatment processes, aiming to mitigate its impact on drinking water sources. In the field of analytical chemistry, the development of sensitive and specific detection methods for Cylindrospermopsin in water samples is critical, utilizing techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS). These studies are essential for the assessment of the ecological risks posed by cyanobacterial toxins and for informing water management strategies.


Cylindrospermopsin (CAS 143545-90-8) References

  1. Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity.  |  Shaw, GR., et al. 2000. Ther Drug Monit. 22: 89-92. PMID: 10688267
  2. Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin.  |  Falconer, IR. and Humpage, AR. 2001. Environ Toxicol. 16: 192-5. PMID: 11339720
  3. The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin.  |  Griffiths, DJ. and Saker, ML. 2003. Environ Toxicol. 18: 78-93. PMID: 12635096
  4. Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes.  |  Froscio, SM., et al. 2003. Environ Toxicol. 18: 243-51. PMID: 12900943
  5. The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice.  |  Reisner, M., et al. 2004. Toxicol Sci. 82: 620-7. PMID: 15342955
  6. Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress.  |  Humpage, AR., et al. 2005. J Toxicol Environ Health A. 68: 739-53. PMID: 16020200
  7. New measurements of cyanobacterial toxins in natural waters using high performance liquid chromatography coupled to tandem mass spectrometry.  |  Hedman, CJ., et al. 2008. J Environ Qual. 37: 1817-24. PMID: 18689743
  8. Morphological cell transformation of Syrian hamster embryo (SHE) cells by the cyanotoxin, cylindrospermopsin.  |  Maire, MA., et al. 2010. Toxicon. 55: 1317-22. PMID: 20144639
  9. Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin.  |  Chernoff, N., et al. 2011. J Appl Toxicol. 31: 242-54. PMID: 20936652
  10. ADMET Evaluation in Drug Discovery. 18. Reliable Prediction of Chemical-Induced Urinary Tract Toxicity by Boosting Machine Learning Approaches.  |  Lei, T., et al. 2017. Mol Pharm. 14: 3935-3953. PMID: 29037046
  11. Cylindrospermopsin toxicity in mice following a 90-d oral exposure.  |  Chernoff, N., et al. 2018. J Toxicol Environ Health A. 81: 549-566. PMID: 29693504
  12. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir.  |  Hawkins, PR., et al. 1985. Appl Environ Microbiol. 50: 1292-5. PMID: 3937492
  13. Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes.  |  Runnegar, MT., et al. 1995. Biochem Pharmacol. 49: 219-25. PMID: 7840799
  14. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans.  |  Terao, K., et al. 1994. Toxicon. 32: 833-43. PMID: 7940590
  15. Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake.  |  Hawkins, PR., et al. 1997. Toxicon. 35: 341-6. PMID: 9080590

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cylindrospermopsin, 50 µg

sc-203014
50 µg
$218.00

Cylindrospermopsin, 100 µg

sc-203014A
100 µg
$366.00