Cyclosporin A-d4 (CAS 59865-13-3 (unlabeled))
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Cyclosporin A-d4 is a deuterated analog of Cyclosporin A used primarily in analytical research to understand the kinetics and metabolic pathways of Cyclosporin A. The incorporation of deuterium, a stable isotope of hydrogen, allows for precise tracking of the compound using mass spectrometry, as it creates a distinct mass difference from the non-labeled substance. In biochemical studies, Cyclosporin A-d4 serves as an internal standard to accurately measure the concentration of Cyclosporin A in biological samples, ensuring the reliability and reproducibility of the data. It is also employed in studies to investigate the environmental fate and transport of Cyclosporin A, as the deuterated compound can act as a tracer without altering the chemical nature of the parent compound. Utilizing Cyclosporin A-d4 provides researchers with a powerful tool to deepen the understanding of the behavior of Cyclosporin A in various systems.
Cyclosporin A-d4 (CAS 59865-13-3 (unlabeled)) References
- Determination of cyclosporine and its metabolites in blood via HPLC-MS and correlation to clinically important parameters. | Vollenbroeker, B., et al. 2005. Transplant Proc. 37: 1741-4. PMID: 15919451
- Ultra fast liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of cyclosporin A, tacrolimus, sirolimus, and everolimus in whole blood using deuterated internal standards for cyclosporin A and everolimus. | Meinitzer, A., et al. 2010. Ther Drug Monit. 32: 61-6. PMID: 20010460
- Two rapid ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) methods with common sample pretreatment for therapeutic drug monitoring of immunosuppressants compared to immunoassay. | Tszyrsznic, W., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 928: 9-15. PMID: 23584041
- Development of rapid methodologies for the isolation and quantitation of drug metabolites by differential mobility spectrometry - mass spectrometry. | Hall, AB., et al. 2012. Int J Ion Mobil Spectrom. 15: PMID: 24311968
- Quantitative determination of four immunosuppressants by high resolution mass spectrometry (HRMS). | Bruns, K., et al. 2016. Clin Chem Lab Med. 54: 1193-200. PMID: 26641969
- Cyclosporins, fungal metabolites with immunosuppressive activities. | von Wartburg, A. and Traber, R. 1988. Prog Med Chem. 25: 1-33. PMID: 3076967
- Quantitation of Cyclosporin A in Cell Culture Media by Differential Mobility Mass Spectrometry (DMS-MS/MS). | Kafle, A., et al. 2020. Methods Mol Biol. 2084: 145-157. PMID: 31729659
- Analysis of Immunosuppressant Drugs in Whole Blood by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). | Pablo, AH., et al. 2020. Curr Protoc Toxicol. 84: e92. PMID: 32436620
- Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers. | Kociszewska-Najman, B., et al. 2020. Nutrients. 12: PMID: 32899873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclosporin A-d4, 1 mg | sc-217987 | 1 mg | $630.00 | |||
Cyclosporin A-d4, 10 mg | sc-217987A | 10 mg | $4896.00 |