Cyclosporin A Antibody (CSZ.22): sc-51856

Cyclosporin A Antibody (CSZ.22) is a mouse monoclonal IgG1 antibody that detects Cyclosporin A protein of Tolypocladium inflatum origin by enzyme-linked immunosorbent assay (ELISA). Cyclosporin A, also referred to as CsA, is a potent immunosuppressive compound derived from the fungus Tolypocladium inflatum, and its discovery in 1971 revolutionized the field of immunopharmacology. This remarkable compound functions primarily by inhibiting calcineurin activity, a critical enzyme in T cell activation, thereby preventing interleukin-2 (IL-2) transcription and effectively modulating immune response. Cyclosporin A′s ability to selectively suppress T cell activity without causing excessive toxicity has made this compound a cornerstone in organ transplant procedures, significantly reducing organ rejection risk. Additionally, Cyclosporin A′s role extends beyond immunosuppression; this compound also inhibits permeability-transition pore opening in mitochondria, contributing to neuroprotective properties. Such unique action allows Cyclosporin A to mitigate damage associated with head trauma and neurodegenerative diseases, highlighting Cyclosporin A′s multifaceted importance in both transplantation and neuroprotection.

The preferred Cyclosporin A antibody is Cyclosporin A Antibody (H4 1.3): sc-69888.