Molecular structure of Cyclosporin A Acetate, CAS Number: 83602-41-9
Cyclosporin A Acetate (CAS 83602-41-9)
Alternate Names:
6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-methyl-2-(methylamino)-6-octenoic acid] Cyclosporin A; B 3-243; O-Acetyl-C91-cyclosporin A; O-Acetylcyclosporin A; SDZ 33-243
Application:
Cyclosporin A Acetate is a non-immunosuppressive analog of Cyclosporin A
CAS Number:
83602-41-9
Molecular Weight:
1244.65
Molecular Formula:
C64H113N11O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cyclosporin A Acetate is a non-immunosuppressive analog of Cyclosporin A. However both Cyclosporin A Acetate and Cyclosporin A are able to inhibit IL-1 and PTH stimulated calcium release. NAG stimulated release by IL-1 is less effective by Cyclosporin A Acetate than Cyclosporin A.
Cyclosporin A Acetate (CAS 83602-41-9) References
- Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro. | Twentyman, PR., et al. 1992. Br J Cancer. 65: 335-40. PMID: 1313690
- The mechanism of bone resorption by cyclosporin: involvement of the NO-cGMP pathway. | Wimalawansa, SM., et al. 2000. J Musculoskelet Neuronal Interact. 1: 141-3. PMID: 15758508
- Modification of cytotoxic drug resistance by non-immuno-suppressive cyclosporins. | Twentyman, PR. 1988. Br J Cancer. 57: 254-8. PMID: 2833299
- Cyclosporin Structure and Permeability: From A to Z and Beyond. | Corbett, KM., et al. 2021. J Med Chem. 64: 13131-13151. PMID: 34478303
- Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. | Schneider, H., et al. 1994. Biochemistry. 33: 8218-24. PMID: 8031755
- Synthesis of the main metabolite (OL-17) of cyclosporin A | Marcel K. Eberle and Francois Nuninger. 1992,. J. Org. Chem. 57, 9,: 2689–2691.
- Cyclosporin A: Regioselective Ring Opening and Fragmentation Reactions via Thioamides. A Route to Semisynthetic Cyclosporins | Marcel K. Eberle, Anne-Marie Jutzi-Eme, and Francois Nuningerc. 1994,. J. Org. Chem. 59, 24,: 7249–7258.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclosporin A Acetate, 100 mg | sc-211155 | 100 mg | $306.00 |