Date published: 2025-11-4

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Cyclopentyl methyl ether (CAS 5614-37-9)

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CAS Number:
5614-37-9
Purity:
≥98%
Molecular Weight:
100.16
Molecular Formula:
C6H12O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cyclopentyl methyl ether (CPME) is an organic compound characterized by its structure, consisting of a cyclopentane ring connected to a methoxy group (-OCH3). This ether is known for its excellent solvency properties combined with a favorable environmental and safety profile, making it a popular solvent in organic synthesis and chemical research. Its molecular structure confers unique physical and chemical properties, such as a high boiling point and low miscibility with water, which are advantageous in various applications. In the field of research, CPME is particularly valued for its use as a green solvent, replacing more hazardous and volatile organic compounds in chemical reactions and processes. Its stability and inertness under acidic and basic conditions make it an ideal medium for conducting complex syntheses, including those involving sensitive reactants. CPME′s low toxicity and low environmental impact also enhance its utility in sustainable chemistry practices. Researchers have utilized CPME in applications ranging from catalysis to the synthesis of pharmaceutical intermediates and fine chemicals. Its ability to dissolve a wide range of organic materials, coupled with its reduced reactivity, facilitates the efficient extraction and purification of reaction products, underscoring its role in improving the safety and environmental aspects of chemical manufacturing and laboratory operations.


Cyclopentyl methyl ether (CAS 5614-37-9) References

  1. Cyclopentyl methyl ether: an alternative solvent for palladium-catalyzed direct arylation of heteroaromatics.  |  Beydoun, K. and Doucet, H. 2011. ChemSusChem. 4: 526-34. PMID: 21337529
  2. Cyclopentyl methyl ether: a green co-solvent for the selective dehydration of lignocellulosic pentoses to furfural.  |  Campos Molina, MJ., et al. 2012. Bioresour Technol. 126: 321-7. PMID: 23128237
  3. The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.  |  Watanabe, K. 2013. Molecules. 18: 3183-94. PMID: 23478516
  4. B(OCH2CF3)3-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether.  |  Karaluka, V., et al. 2015. Org Biomol Chem. 13: 10888-94. PMID: 26366853
  5. 2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis.  |  Jad, YE., et al. 2016. Amino Acids. 48: 419-26. PMID: 26403847
  6. Cyclopentyl Methyl Ether: An Elective Ecofriendly Ethereal Solvent in Classical and Modern Organic Chemistry.  |  Azzena, U., et al. 2019. ChemSusChem. 12: 40-70. PMID: 30246930
  7. Cyclopentyl Methyl Ether (CPME): A Versatile Eco-Friendly Solvent for Applications in Biotechnology and Biorefineries.  |  de Gonzalo, G., et al. 2019. ChemSusChem. 12: 2083-2097. PMID: 30735610
  8. Bypassing Osmotic Shock Dilemma in a Polystyrene Resin Using the Green Solvent Cyclopentyl methyl Ether (CPME): A Morphological Perspective.  |  Al Musaimi, O., et al. 2019. Polymers (Basel). 11: PMID: 31086118
  9. Catalyst-free Synthesis of Aminomethylphenol Derivatives in Cyclopentyl Methyl Ether via Petasis Borono-Mannich Reaction.  |  Di, JQ., et al. 2021. Curr Org Synth. 18: 294-300. PMID: 33327919
  10. A novel cyclopentyl methyl ether electrolyte solvent with a unique solvation structure for subzero (-40 °C) lithium-ion batteries.  |  Ramasamy, HV., et al. 2022. Chem Commun (Camb). 58: 5124-5127. PMID: 35380137

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cyclopentyl methyl ether, 100 ml

sc-252651
100 ml
$61.00

Cyclopentyl methyl ether, 1 L

sc-252651A
1 L
$172.00