Cyclopenin CAS: 19553-26-5
MF: C17H14N2O3
MW: 294.3
An intermediate in the biosynthesis of the viridicatins.

Cyclopenin (CAS 19553-26-5)

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Application: Cyclopenin is an intermediate in the biosynthesis of the viridicatins
CAS Number: 19553-26-5
Purity: >99%
Molecular Weight: 294.3
Molecular Formula: C17H14N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicllium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of the viridicatins, strong inhibitors of the tumor necrosis factor alpha (TNFα)-induced replication of human immunodeficiency virus (HIV).


References

1. Studies in the biochemistry of microorganisms. 93. Cyclopenin, a nitrogen-containing metabolic product of Penicillium cyclopium Westling. Bracken A. et al. Biochem J. 1954, 57, 587.
2. Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumour necrosis factor alpha-induced human immunodeficiency virus replication. Heguy A. et al. Antivir. Chem. Chemother. 1998, 9, 149.

Physical State :
Solid
Derived From :
Penicillium sp.
Solubility :
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
271117
SMILES :
CN1C(=O)C2=CC=CC=C2NC(=O)C13C(O3)C4=CC=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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