Molecular structure of Cyclopamine-KAAD, CAS Number: 306387-90-6
Cyclopamine-KAAD (CAS 306387-90-6)
See product citations (3)
CAS Number:
306387-90-6
Purity:
≥70%
Molecular Weight:
698.0
Molecular Formula:
C44H63N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Cyclopamine-KAAD is a potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity. Cyclopamine-KAAD binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Cyclopamine-KAAD also suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity.
Cyclopamine-KAAD (CAS 306387-90-6) References
Watkins, D.N., et al. 2003. Nature 422, 313. Berman, D.M., et al. 2002. Science 297, 1559. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Chen, J.K., et al. 2002. Genes Dev. 16, 2743. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. Taipale, J., et al. 2000. Nature 406, 1005.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclopamine-KAAD, 100 µg | sc-221448 | 100 µg | $380.00 | |||
Cyclopamine-KAAD, 250 µg | sc-221448A | 250 µg | $645.00 |