Cyclohexyl-n-hexyl-β-D-maltoside (CAS 228579-27-9)

Cyclohexyl-n-hexyl-β-D-maltoside, a non-ionic detergent, has emerged as a crucial tool in membrane protein research owing to its unique properties and diverse applications. As a mild detergent, it effectively solubilizes membrane proteins while maintaining their native structure and function, making it ideal for membrane protein purification and crystallization studies. Its ability to mimic the lipid bilayer environment facilitates the extraction and stabilization of membrane proteins, enabling their biochemical and biophysical characterization. Furthermore, Cyclohexyl-n-hexyl-β-D-maltoside has been extensively utilized in various structural biology techniques, including X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), to explain the three-dimensional structures of membrane proteins. By providing a well-defined membrane-like environment, this detergent enhances the stability of membrane proteins and improves the resolution of structural studies, thereby advancing our understanding of their molecular mechanisms and interactions. Additionally, Cyclohexyl-n-hexyl-β-D-maltoside has found applications in drug discovery and development, particularly in screening assays and structure-based drug design targeting membrane proteins, underscoring its significance in biomedical research and pharmaceutical innovation.