Date published: 2025-12-6

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Cyclo(-Ser-Tyr) (CAS 21754-31-4)

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Alternate Names:
(3S,6S)-3-(hydroxymethyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione; Cyclo(-L-Ser-L-Tyr)
CAS Number:
21754-31-4
Molecular Weight:
250.25
Molecular Formula:
C12H14N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cyclo(-Ser-Tyr), a cyclic dipeptide also known as a diketopiperazine, consists of the amino acids serine and tyrosine linked in a cyclic structure. This compound serves as a tool in biochemistry and molecular biology research, particularly in studies focusing on peptide stability, protein-protein interactions, and the modulation of biological pathways. Cyclo(-Ser-Tyr) exhibits unique properties due to its cyclic nature, which imparts greater stability against enzymatic degradation compared to its linear counterparts. This enhanced stability makes it an invaluable scaffold for the synthesis of more complex peptides and for the exploration of peptide-based therapeutics. Additionally, its ability to influence specific receptor pathways without the direct involvement typical of other compounds allows researchers to dissect molecular mechanisms with precision, providing insights into cellular signaling processes and the intricate web of biological interactions.


Cyclo(-Ser-Tyr) (CAS 21754-31-4) References

  1. Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1.  |  Mizuma, T., et al. 2002. J Pharm Pharmacol. 54: 1293-6. PMID: 12356285
  2. Development of LC-MS/MS analysis of cyclic dipeptides and its application to tea extract.  |  Yamamoto, K., et al. 2016. Biosci Biotechnol Biochem. 80: 172-7. PMID: 26299992
  3. Combination of cheminformatics and bioinformatics to explore the chemical basis of the rhizomes and aerial parts of Dioscorea nipponica Makino.  |  Li, XZ., et al. 2017. J Pharm Pharmacol. 69: 1846-1857. PMID: 28940203
  4. Intestinal absorption of stable cyclic dipeptides by the oligopeptide transporter in rat.  |  Mizuma, T., et al. 1998. J Pharm Pharmacol. 50: 167-72. PMID: 9530984

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cyclo(-Ser-Tyr), 100 mg

sc-460344A
100 mg
$153.00

Cyclo(-Ser-Tyr), 250 mg

sc-460344
250 mg
$190.00

Cyclo(-Ser-Tyr), 1 g

sc-460344B
1 g
$536.00