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Cyclo(-Pro-Val) is a diketopiperazines which shows antifungal activity, has also been isolated from microorganisms and further natural sources. Cyclo(-Pro-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of the cyclo(L-Pro-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signaling systems.
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