Date published: 2026-4-5

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Cyclo(-Leu-Pro) (CAS 2873-36-1)

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Alternate Names:
Cyclo(-L-Leu-L-Pro)
Application:
Cyclo(-Leu-Pro) is a cyclic dipeptide containing leucine and proline
CAS Number:
2873-36-1
Purity:
≥98%
Molecular Weight:
210.27
Molecular Formula:
C11H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cyclo(-Leu-Pro), a cyclic dipeptide, has demonstrated its utility in research focused on enhancing peptide stability and conferring resistance to proteolytic degradation. The cyclic nature of this compound confers a degree of stability against enzymatic degradation, making it an excellent subject for investigating the longevity of peptide-based structures in biological systems. Researchers also explore its potential as a modulator of various biological processes due to its structural mimicry of certain bioactive peptides. In addition, Cyclo(-Leu-Pro) has been instrumental in the study of peptide-receptor interactions, providing insights into the structural requirements for binding and activity at peptide receptors. Its use extends to the field of materials science as well, where its incorporation into polymers and hydrogels is examined to enhance the biological functionality and durability of these materials.


Cyclo(-Leu-Pro) (CAS 2873-36-1) References

  1. Isolation and characterization of Streptomyces sp KH-614 producing anti-VRE (vancomycin-resistant enterococci) antibiotics.  |  Rhee, KH. 2002. J Gen Appl Microbiol. 48: 321-7. PMID: 12682870
  2. Identification of antifungal compounds produced by Lactobacillus casei AST18.  |  Li, H., et al. 2012. Curr Microbiol. 65: 156-61. PMID: 22580887
  3. Butyrolactone and cycloheptanetrione from mangrove-associated fungus Aspergillus terreus.  |  Shen, Y., et al. 2012. Chem Pharm Bull (Tokyo). 60: 1437-41. PMID: 23124567
  4. Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2Δ by HRGC/MS using stable isotope dilution assay.  |  Axel, C., et al. 2014. Anal Bioanal Chem. 406: 2433-44. PMID: 24477717
  5. Association of Synergistetes and Cyclodipeptides with Periodontitis.  |  Marchesan, JT., et al. 2015. J Dent Res. 94: 1425-31. PMID: 26198391
  6. Proline-Based Cyclic Dipeptides from Korean Fermented Vegetable Kimchi and from Leuconostoc mesenteroides LBP-K06 Have Activities against Multidrug-Resistant Bacteria.  |  Liu, R., et al. 2017. Front Microbiol. 8: 761. PMID: 28512456
  7. Whole Genome Sequencing and Metabolomic Study of Cave Streptomyces Isolates ICC1 and ICC4.  |  Gosse, JT., et al. 2019. Front Microbiol. 10: 1020. PMID: 31134037
  8. l-Proline-based-cyclic dipeptides from Pseudomonas sp. (ABS-36) inhibit pro-inflammatory cytokines and alleviate crystal-induced renal injury in mice.  |  Begum Ahil, S., et al. 2019. Int Immunopharmacol. 73: 395-404. PMID: 31151077
  9. Secondary metabolites of Galactomyces geotrichum from Laminaria japonica ameliorate cognitive deficits and brain oxidative stress in D-galactose induced Alzheimer's disease mouse model.  |  Wang, F., et al. 2021. Nat Prod Res. 35: 5323-5328. PMID: 32292060
  10. Lactococcus lactis subsp. cremoris of Plant Origin Produces Antifungal Cyclo-(Leu-Pro) and Tetradecanoic Acid.  |  Gajbhiye, M. and Kapadnis, B. 2021. Indian J Microbiol. 61: 74-80. PMID: 33505095
  11. Unambiguous Stereochemical Assignment of Cyclo(Phe-Pro), Cyclo(Leu-Pro), and Cyclo(Val-Pro) by Electronic Circular Dichroic Spectroscopy.  |  Domzalski, A., et al. 2021. Molecules. 26: PMID: 34641525
  12. Streptococcus mutans and Candida albicans Biofilm Inhibitors Produced by Lactiplantibacillus plantarum CCFM8724.  |  Li, J., et al. 2022. Curr Microbiol. 79: 143. PMID: 35325333
  13. Quorum Sensing Inhibitory and Quenching Activity of Bacillus cereus RC1 Extracts on Soft Rot-Causing Bacteria Lelliottia amnigena.  |  Kachhadia, R., et al. 2022. ACS Omega. 7: 25291-25308. PMID: 35910130

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cyclo(-Leu-Pro), 100 mg

sc-285317B
100 mg
$124.00

Cyclo(-Leu-Pro), 250 mg

sc-285317
250 mg
$259.00

Cyclo(-Leu-Pro), 1 g

sc-285317A
1 g
$756.00

Cyclo(-Leu-Pro), 5 g

sc-285317C
5 g
$2227.00