Cyclo(-His-Pro) (CAS 53109-32-3)
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Cyclo(-His-Pro) is a cyclic dipeptide composed of the amino acids histidine and proline. It is involved in signaling pathways related to cell growth, differentiation, and immune response. The presence of Cyclo(-His-Pro) can modulate the activity of certain enzymes and receptors, influencing cellular processes such as gene expression and protein synthesis. This dipeptide plays a role in regulating the release of certain hormones and neurotransmitters. Cyclo(-His-Pro) has antioxidant properties, protecting cells from oxidative damage. Its ability to interact with specific cellular targets makes it an important molecule in understanding the mechanisms of cellular function and response to external stimuli.
Cyclo(-His-Pro) (CAS 53109-32-3) References
- Focus on cyclo(His-Pro): history and perspectives as antioxidant peptide. | Minelli, A., et al. 2008. Amino Acids. 35: 283-9. PMID: 18163175
- Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence. | Minelli, A., et al. 2009. J Cell Mol Med. 13: 1149-61. PMID: 18373731
- Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. | Minelli, A., et al. 2009. J Neurochem. 111: 956-66. PMID: 19735445
- Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. | Minelli, A., et al. 2012. Int J Biochem Cell Biol. 44: 525-35. PMID: 22185821
- Neurobiology of cyclo(His-Pro). | Prasad, C. 1989. Ann N Y Acad Sci. 553: 232-51. PMID: 2541650
- The Role of Cyclo(His-Pro) in Neurodegeneration. | Grottelli, S., et al. 2016. Int J Mol Sci. 17: PMID: 27529240
- Zinc plus cyclo-(His-Pro) promotes hippocampal neurogenesis in rats. | Choi, BY., et al. 2016. Neuroscience. 339: 634-643. PMID: 27773743
- Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment. | Song, MK., et al. 2017. BBA Clin. 7: 41-54. PMID: 28070499
- Potential Influence of Cyclo(His-Pro) on Proteostasis: Impact on Neurodegenerative Diseases. | Grottelli, S., et al. 2018. Curr Protein Pept Sci. 19: 805-812. PMID: 29708066
- Cyclo(His-Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells. | Grottelli, S., et al. 2019. Mol Cell Neurosci. 94: 23-31. PMID: 30439413
- Is all cyclo(His-Pro) derived from thyrotropin-releasing hormone? | Prasad, C., et al. 1987. Neurochem Res. 12: 767-74. PMID: 3118225
- Cyclo(His-Pro): its distribution, origin and function in the human. | Prasad, C. 1988. Neurosci Biobehav Rev. 12: 19-22. PMID: 3287238
- Cyclo(His-Pro) Exerts Protective Carbonyl Quenching Effects through Its Open Histidine Containing Dipeptides. | Regazzoni, L., et al. 2022. Nutrients. 14: PMID: 35565743
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclo(-His-Pro), 25 mg | sc-294122 | 25 mg | $165.00 | |||
Cyclo(-His-Pro), 50 mg | sc-294122A | 50 mg | $258.00 | |||
Cyclo(-His-Pro), 100 mg | sc-294122B | 100 mg | $320.00 | |||
Cyclo(-His-Pro), 250 mg | sc-294122C | 250 mg | $620.00 |