Date published: 2025-10-21

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Cyclo-Gly-Pro (CAS 3705-27-9)

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Alternate Names:
cyclo-Glycyl-L-Proline; cyclo-GP; (S)-3,6-Dioxohexahydropyrrolo[1,2-a]pyrazine
Application:
Cyclo-Gly-Pro is a neuro-protective compound
CAS Number:
3705-27-9
Purity:
≥98%
Molecular Weight:
154.17
Molecular Formula:
C7H10N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cyclo-Gly-Pro, also known as cyclo(Gly-Pro) or cyclo(glycyl-prolyl), is a dipeptide composed of glycine and proline amino acids forming a cyclic structure. This compound is of particular interest in biochemical and neurological research due to its presence in the human body and potential physiological roles. In research, Cyclo-Gly-Pro is often used to study its influence on peptide and protein folding, as the introduction of a proline residue in peptides can significantly affect their conformational stability. Additionally, this cyclic dipeptide is investigated for its role in the regulation of neurotransmitter release and its potential modulatory effects on neural communication. Researchers also explore Cyclo-Gly-Pro′s involvement in the mechanisms of cellular protection and stress response, as it is known to be produced during times of oxidative stress. The insights gained from studying Cyclo-Gly-Pro are valuable in understanding the complex interactions within biological systems, particularly in the context of protein biochemistry and neurobiology.


Cyclo-Gly-Pro (CAS 3705-27-9) References

  1. Cyclo-Gly-Pro, a cyclic dipeptide, attenuates nociceptive behaviour and inflammatory response in mice.  |  Ferro, JN., et al. 2015. Clin Exp Pharmacol Physiol. 42: 1287-95. PMID: 26277051
  2. Identification of chemical markers in Cordyceps sinensis by HPLC-MS/MS.  |  Hu, H., et al. 2015. Anal Bioanal Chem. 407: 8059-66. PMID: 26302964
  3. Restoration of Cyclo-Gly-Pro-induced salivary hyposecretion and submandibular composition by naloxone in mice.  |  Melo, IS., et al. 2020. PLoS One. 15: e0229761. PMID: 32155179
  4. Combined mass spectrometry-guided genome mining and virtual screening for acaricidal activity in secondary metabolites of Bacillus velezensis W1.  |  Li, X., et al. 2021. RSC Adv. 11: 25441-25449. PMID: 35478879
  5. Recent Advances in the Research on the Anticyanobacterial Effects and Biodegradation Mechanisms of Microcystis aeruginosa with Microorganisms.  |  Kong, Y., et al. 2022. Microorganisms. 10: PMID: 35744654
  6. Algicidal activity of Morganella morganii against axenic and environmental strains of Microcystis aeruginosa: Compound combination effects.  |  Mankiewicz-Boczek, J., et al. 2022. Chemosphere. 309: 136609. PMID: 36195129
  7. Gly-Pro protects normal human dermal fibroblasts from UVA-induced damages via MAPK-NF-κB signaling pathway.  |  Liu, S., et al. 2022. J Photochem Photobiol B. 237: 112601. PMID: 36434834
  8. Curcumae Rhizoma - combined with Sparganii Rhizoma in the treatment of liver cancer: Chemical analysis using UPLC-LTQ-Orbitrap MSn, network analysis, and experimental assessment.  |  Wei, J., et al. 2022. Front Pharmacol. 13: 1027687. PMID: 36561345
  9. Identification of serum exosomal metabolomic and proteomic profiles for remote ischemic preconditioning.  |  Du, Y., et al. 2023. J Transl Med. 21: 241. PMID: 37009888
  10. Metabolomic and Proteomic Identification of Serum Exosome for Hypoxic Preconditioning Participants.  |  Fan, F., et al. 2023. Oxid Med Cell Longev. 2023: 5509913. PMID: 37089582

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cyclo-Gly-Pro, 10 mg

sc-252644
10 mg
$104.00